Current Issue ( Vol. : 6, Issue: 4, October- December 2017)   


Title: FACTORS AFFECTING ADHERENCE IN ASTHMA CHILDREN’S AND ASSESS THE IMPACT OF PATIENT COUNSELING
Author: Arul Prakasam K C* Sethilkumar N
Keyword: Bronchial asthma, Non-adherence, Health education
Page No: 60-66
Abstract: Objectives: To study the adherence in Asthma children’s and to assess the factors contributing to non-adherence. Methodology: A total of 368 patients with bronchial asthma were studied over a period of two years at two different hospitals in Tamilnadu in India. Once included in the study, patient’s follow-up was done for three months. Percentage adherence therapy was calculated. If patient was non-compliant to the therapy, were employed various health education strategies to improve the adherence in these patients. Results: A total of 368 patients with bronchial asthma who were started therapy over duration of two years were included in the study. At the end of three months, it was observed that, 344 patients (93.49%) were having non-adherence. Factors that were associated with poor adherence were: lower educational level status, poor socio-economic status, cumbersome regimens, fears about side effects, anger about condition or its treatment, forgetfulness or complacency and patient’s ill attitudes toward health. After employing various strategies for improving patients, the adherence rate improved patients in 142 patients (41.27.3%) among the earlier non-adherence patients, while the remaining 202 patients (58.72%) were found to be non-adherence even after various educational techniques. Conclusions: Non adherence in asthma management is a fact of life and improving strategy probably will be as effective as a good physician–patient relationship. We observed, despite institution of various education strategies, it is difficult to improve adherence towards aerosol therapy in patients with bronchial asthma. Key Words: Bronchial asthma, Non-adherence, Health education Download PDF


Title: A STUDY ON EVALUATION OF ANTHRACYCLINE INDUCED CARDIOTOXICITY IN CHEMOTHERAPY PATIENTS IN A TERTIARY CARE HOSPITAL
Author: Neethu Muralidharan*, Geetha K, Dr. Ramaprabha Hari
Keyword: Anthracyclines, Cardiotoxicity, Age, Gender, Combination Therapy
Page No: 67-78
Abstract: A prime limiting factor in the administration of anthracyclines is cardiotoxicity. AIM : was to evaluate anthracycline induced cardiotoxicity among chemotherapy patients in a tertiary care hospital. Materials and Methods: A retrospective observational study was carried among patients treated with anthracyclines alone or in combination with other chemo drugs. One hundred and fifty patients were enrolled and data collection form was designed to collect data on social demographic characteristics, parameters like Type, Root and Duration of administration, Type of Regiment administered, Cardiac assessment of the patients before, during and after anthracycline chemotherapy, any reassessment done after sixth cycle of chemotherapy from patient medical records. Results and Discussion: Out of 150 patients 7 were found to be cardiotoxic (2 males and 5 females (p<0.045)), 6 patients of age above 51 were cardiotoxic (p<0.025). 2 patients (n=43) with 30 min duration of administration, 3 patient (n=71) with 1 hour duration, 2 patients (n=9) with 2 hour duration (p<0.010) were cardiotoxic. 1 patient (n=54) and 6 patients (n=96) were cardiotoxic after cycle 6 and cycle 8 respectively (p<0.022). 3 patients (n=28) of anthracycline and cyclophosphamide combination showed cardiotoxicity (p<0.032). Conclusion: Current study concludes that the prevalence of anthracycline induced cardiotoxicity was low due to close and strict monitoring of patients before, during and after each cycle of chemotherapy and even during the follow up which may extend up to several years. Keywords: Anthracyclines, Cardiotoxicity, Age, Gender, Combination Therapy Download PDF


Title: DEVELOPMENT AND VALIDATION OF ANALYTICAL METHOD FOR SIMULTANEOUS ESTIMATION OF OFLOXACIN AND OMEPRAZOLE IN BULK DRUG
Author: Sarmita Rania, Manish Majumder, Amit Sharma, Amit Rai, Durgadas Anghore
Keyword: Simultaneous quantitative determination, UV, HPLC and Ofloxacin and Omeprazole.
Page No: 79-87
Abstract: Ofloxacin (OFL) and Omeprazole (OMP) are synthetic drugs active against H. Pylori. UV-Spectrophotometric analytical method was validated to assay Ofloxacin and Omeprazole in tablet. Measurements were taken at 298 and 302 nm using methanol and water as solvent. This new method was developed and validated in accordance with ICH requirements, which include linearity, precision, accuracy, specificity, detection and quantitation limits. The simultaneous estimation method demonstrated good linearity over the range of 5-30 µg/mL. The mean percentage recoveries were 101.11, 100.86 of OMP and OFL. In Derivative spectroscopy, percentage recovery of OMP and OFL were 101.13, 100.86. In Zero crossing method, values found were 101.73, 101.53 OMP and OFL respectively. The repeatability values were found 0.0045, 0.0053 for OMP, 0.0058 and 0.0054 for OFL in simultaneous method. In first order derivative spectroscopy, values were found 0.0045, 0.0053 for OMP, 0.0058 and 0.0054 for OFL at 225 and 235 nm. In simultaneous estimation method, LOD values were found to be 2.29, 1.56 and LOQ values were 2.86, 2.72 for OFL and OMP respectively, in first order derivatives, LOD values were found to be 2.65 and 2.08. LOQ values were 4.75, 3.92 for OMP and OFL respectively, In Q Analysis method, LOD values were found to be 1.97 and 2.64. LOQ values were 3.32, 3.84 for OMP and OFL respectively. In house Formulation by simultaneous equation method showed that the percentages 101.98, 101.21 and 102.31, 102.01 for OMP and OFL. In first order derivative spectroscopy method, values were 102.31, 102.09 for OMP and 102.12, 101.96 for OFL, In Q-Analysis method, values were found 102.65, 102.41 for OMP and 102.32, 101.78 for OFL. The proposed method might be applied in routine quality control in the pharmaceutical industries since it is precise, accurate, simple, and economic, produces very low amounts of solvents and residues. .Keywords: Simultaneous quantitative determination, UV, HPLC and Ofloxacin and Omeprazole. Download PDF