Current Issue ( Vol. : 7, Issue: 1, January- March 2018)   


Title: ANTICONVULSANT SCREENING OF HYDRO-ALCOHOLIC ROOT EXTRACT OF BERBERIS ARISTATA IN MICE
Author: Chauhan S. Suchita and Sharma K. Hemant
Keyword: Anti-convulsant, Berberis aristata, MES, Pentylenetetrazole, Diazepam, Epilepsy.
Page No: 01-06
Abstract: Objective: To explore anti-convulsant potential of hydro-alcoholic extract of Berberis aristata (B. aristata) from pentylenetetrazole-induced and maximal electroshock (MES) seizure test. Material & Me thods: The test groups receive different doses (50, 100, 250 and 500 mg/kg) of the hydro-alcoholic extract; however positive control (standard) Phenobarbitone (20 mg/kg) using for Pentylenetetrazole-induced Seizure and Diazepam (1mg/kg) used as standard for maximal electroshock induced seizure. Swiss albino mice weigh about 20-25 g of either sex selected for the investigation. Results: Phytochemical investigation reveals that occurrence of alkaloids, flavonoids in the hydro-alcoholic root extract of Berberis aristata. Acute toxicity study shows no morality action up to 1000 mg/kg dose after 72 h observation. Hydro-alcoholic extract of B. aristata offered a concentration depending upon act of pentylenetetrazole-induced seizure (PTZ) and maximal electroshock induced seizure (MES). Conclusions: These finding suggest that hydro-alcoholic extract of B. aristata remarkable effect in the treatment in epilepsy. Key-words: Anti-convulsant, Berberis aristata, MES, Pentylenetetrazole, Diazepam, Epilepsy. Download PDF


Title: 31 QBD APPROACH IN FORMULATION AND EVALUATION OF ANTIMALERIAL AND ANTIBIOTICS AS COMBINATION THERAPIES
Author: Vilas S Jadhav *and Dr. Deenanath Jhade
Keyword: Azithromycin, Chloroquine, Quality By Design, Malaria, Fix dose combination.
Page No: 07-13
Abstract: Since malaria is an illness that may rapidly progress to severe disease and even death, early diagnosis and prompt treatment of acute malaria episodes is an important strategy to reduce morbidity and mortality. The first and most important role of diagnosis is in patient management. Currently there is several medicines are available in the market and containing individual drugs. The major challenge in the malaria to provide or prescribe required dose to cure it in due course of time. The major part covered here to develop the combination therapy required to treat malaria to avoid over or low dose during the treatment. The main drug used in the treatment is Chloroquine and Azithromycin to cure in shortest period of time. In present invention, the development of fix dose combination of Azithromycin and Chloroquine required treating malaria as most effective treatment. Based on overall literature search and studies, it was found that Azithromycin 250mg and Chloroquine 200mg are most suitable strength and combination to be used to trate the malaria. The objective of the present study was to formulate suspension of Azithromycin dihydrate (AZT) and Chloroquine (CQ) as fix dose combination useful to treat Malaria. Individually, Azithromycin and Chloroquine tablets are available in the market to treat malaria. However, there is no fix treatment dose are given during treatment. The present study is to develop safest and effective fix dose combination of Azithromycin and Chloroquine tablets. Key words: Azithromycin, Chloroquine, Quality By Design, Malaria, Fix dose combination. Download PDF


Title: A REVIEW ON PHYSICOCHEMICAL ANALYSIS OF SOLID BIOMEDICAL WASTE PRODUCT OF DIFFERENT HOSPITALS OF METRO CITIES
Author: Kothawade Harshad Sharad#, Dr. Rajendra Chouksey,
Keyword: Biomedical waste, Waste disposal, Waste management, Physicochemical
Page No: 14-18
Abstract: This work discussed about Bio-medical waste’ means any solid and/or liquid waste including its container and any intermediate product, which is generated during the diagnosis, treatment or immunizatio n of human beings or animals or in research pertaining thereto or in the production or testing thereof. The physico-chemical and biological nature of these components, their toxicity and potential hazard are different, necessitating different methods / options for their treatment / disposal. Hospital waste refers to all waste generated, discarded and not intended for further use in the hospital. Improper handling of this waste affects not only medical personnel, doctors who came in contact with medical waste, but also Nurses, Para-medical staff, Ward Boy, Workers, Waste pickers and citizens at large. Solids waste generated from medical institutions need to be handled very carefully as these wastes may contain infectious material. Keywords: Biomedical waste, Waste disposal, Waste management, Physicochemical Download PDF


Title: IMPLEMENTATION OF CLEANING VALIDATION PROGRAM IN FORMULATION MANUFACTURING PLANT
Author: Pankaj P Chandratreya and Dr. Deenanath Jhade
Keyword: Validation, Cleaning Validation, Pharmaceuticals
Page No: 19-27
Abstract: Equipment cleaning and equipment cleaning validation are two activities that play a critical role in preventing risk to patients by assuring that cross-contamination between products is curtailed to a cceptable levels. Incomplete or incorrect cleaning can lead to contaminated product, with residues from previous product batches, cleaning agent and / or other extraneous material being introduced into the product manufacturing process. Cleaning validation is important as current trends show an increase in potent and complex drug substances and biotechnology products. This article will cover all elements of cleaning validation in pharma industry. Index Terms: Validation, Cleaning Validation, Pharmaceuticals Download PDF


Title: PHYSICOCHEMICAL ANALYSIS OF SOLID BIOMEDICAL WASTE PRODUCT OF DIFFERENT HOSPITALS OF METRO CITIES
Author: Kothawade Harshad Sharad#, Dr. Rajendra Chouksey
Keyword: Biomedical waste, Waste disposal, Waste management, Physicochemical
Page No: 28-33
Abstract: Biomedical waste management is increasingly being considered due to the recent regulation of biomedical waste (Management and Handling Rules, 1998). Inadequate treatment of biomedical waste can pose r isks for Health workers, patients, communities and their environment. This study was done to physicochemical Analysis of Solid Biomedical Waste Product of Different Hospital of Metro cities. Several healthcare facilities were identified using a modified questionnaire for biomedical waste management. This questionnaire was prepared by the World Health Organization (WHO) for the purpose of evaluation Treatment systems for the disposal of biomedical waste. The risks associated with the mismanagement of biomedical waste were identified in the existing system. Development of policies, plans, and waste management Protocols are recommended, in addition to the proper waste management training programs for all Health workers. Keywords: Biomedical waste, Waste disposal, Waste management, Physicochemical Download PDF


Title: OVERVIEW OF CLEANING VALIDATION IN PHARMACEUTICAL INDUSTRY
Author: Pankaj P Chandratreya and Dr. Deenanath Jhade
Keyword: Cleaning, Chemical, Decomposition Residues
Page No: 34-42
Abstract: An essential part of any pharmaceutical manufacturing facility which operates under cGMP Guidelines and adheres to Quality Systems Regulations (QSR), is the availability of well-developed and validate d cleaning procedures for all installed equipment. This will ensure that the cleaned equipment is free from residues of active ingredient from the previous product manufactured on that equipment and also from traces of detergent, if used in cleaning process. Additionally, the equipment will also be free from microbial contamination which can be carried forward into the next batch.Documented evidence that demonstrates effectiveness of the cleaning methods employed within the facility to consistently reduce potential carryover of product (including intermediates and impurities), cleaning agents and extraneous material into subsequent product to levels which are below predetermined limits is the key to produce quality products. Keywords: Cleaning, Chemical, Decomposition Residues Download PDF


Title: FORMULATION AND EVALUATION OF ANTIMALERIAL AND ANTIBIOTICS AS COMBINATION THERAPIES
Author: Vilas S Jadhav *, Dr. Deenanath Jhade
Keyword: Azithromycin, Chloroquine, Fix dose combination, Malaria, Disintegration time;
Page No: 43-48
Abstract: Since malaria is an illness that may rapidly progress to severe disease and even death, early diagnosis and prompt treatment of acute malaria episodes is an important strategy to reduce morbidity and mortality. The first and most important role of diagnosis is in patient management. Currently there is several medicines are available in the market and containing individual drugs. The major challenge in the malaria to provide or prescribe required dose to cure it in due course of time. The major part covered here to develop the combination therapy required to treat malaria to avoid over or low dose during the treatment. The main drug used in the treatment is Chloroquine and Azithromycin to cure in shortest period of time. In present invention, the development of fix dose combination of Azithromycin and Chloroquine required treating malaria as most effective treatment. Based on overall literature search and studies, it was found that Azithromycin 250mg and Chloroquine 200mg are most suitable strength and combination to be used to trite the malaria. The objective of the present study was to formulate suspension of Azithromycin dihydrate (AZT) and Chloroquine (CQ)as fix dose combination useful to treat Malaria. Individually, Azithromycin and Chloroquine tablets are available in the market to treat malaria. However, there is no fix treatment dose are given during treatment. The present study is to develop safest and effective fix dose combination of Azithromycin and Chloroquine tablets. Key words: Azithromycin, Chloroquine, Fix dose combination, Malaria, Disintegration time; Download PDF