Current Issue ( Vol. : 6, Issue: 1, January- March 2018)   


Title: DEVELOPMENT AND VALIDATION OF HPLC METHOD FOR THE IGURATIMOD
Author: Ravindra B. Nehete and Pushpendra Sharma
Keyword: Iguratimod, validation, development, stability indicating methodology.
Page No: 01-08
Abstract: Analytical method with accuracy, precision and stability indicting was developed for Iguratimod, achieved the required chromatographic separation by High pressure liquid chromatography (HPLC) techniqu e. HPLC method with accuracy, precision, robustness and stability indicating was developed and optimized for quantitative evaluation of Iguratimod as active pharmaceutical ingredient. Chromatographic separation for Iguratimod and its related compounds was achieved by using analytical column with stationary phase Inertsil ODS-3 (Dimension: length 150mm, internal diameter 4.6mm and particle size 5µ) and mobile phase (Buffer and acetonitrile in gradient proportion) at flow rate 1.0ml/minute with detection at 257nm. Squared correlation coefficient (r2) was observed more than 0.999 with concentration window of 12.5 to 75µg/ml. Iguratimod was retained at about 19.0±2.0 minutes. Forced degradation study for Iguratimod was carried out under the stress condition to get required degradation by using acid, base, thermal, photolytic and oxidation by hydrogen peroxide. Degradation products which are generated during stress condition did not interfere to active ingredient, Iguratimod. This analytical method optimized, validated for all the parameters specified in ICH guideline, to get results selective, accurate and precise in presence of degradation impurities. Keywords: Iguratimod, validation, development, stability indicating methodology. Download PDF


Title: A STUDY ON THE EFFECT OF EXTRACURRICULAR ACTIVITIES ON ACADEMIC ACHIEVEMENT
Author: SK Habib
Keyword: Extracurricular Activity, Academic Achievement,Senior Secondary,High Grade Point Average
Page No: 09-16
Abstract: The present study reveals the fact that involvement in the extracurricular activities produces its effect on academic performance of the students. Most of the studies have been carried out and they ha ve revealed the fact that particular extracurricular activities certainly effects on the academic achievement of the students. The purpose of this study is to establish that extra-curricular activities in which school students participate have a positive effect on their academic achievements. The study was conducted by using the questionnaire filling technique which was distributed among 171 students of the class Vlll, lX & X of Al-Ameen Mission School, Khalisani, Uluberia, Howrah, West Bengal. The study gave the fact that according to the students involved in any kind of sports, participating in dramatic and other literary activities positively affects their academic performance, while watching the television has also some positive impact on academic performance. So, it can be deduced from the study that extra-curricular activities affect academic achievements of the students and this impact also depends upon those activities in which the students are keenly involved.Download PDF


Title: STUDY THE EXTRACTION & ANTIMICROBIAL EFFICACY OF TRIPHALA
Author: Mrs. Shraddha Vikrant Gupta, Dr. Surendra Sarsaiya
Keyword: Triphala extraction, antibiotic efficacy, pharmacognostic, fruits, crude drug.
Page No: 17-19
Abstract: In the present study we have to deal with Triphala extraction and its antibiotic efficacy. Triphala is an herbal formula, contains equal proportion of the three important fruits viz. Emblica officinal is, Terminalia chebula, & Terminalia bellerica, this preparation is known to be a safe hypoglycemic agent. Its fruit is olive green in colour. From powdered crude drug using methanol as solvent, separating active material is extraction. Soxhlet assembly is used for extracting the phytochemicals. Antibiotic activity can be found by the preparation of inoculums of E.coli and S.aureus strains in NAM media. The result of present study shows that the Triphala extraction has pharmacognostic activity.Download PDF


Title: STUDY OF GROWTH, SECONDARY METABOLITIES AND GLUCOSINOLATE CONTENT IN CARDAMINE HIRSUTA V/S BRASSICA JUNCEA (INDIAN MUSTARD)
Author: Mona Kejariwal*, Dale Rodrigues and Harshada Gowda
Keyword: Cardamine hirsuta L., qualitative analysis, glucosinolates.
Page No: 20-27
Abstract: Comparative studies of secondary metabolites and glucosinolate content in Cardamine hirsuta L. v/s Brassica juncea (Indian mustard) were carried out. Comparative studies of secondary metabolites and g lucosinolate contents in Cardamine hirsuta L. v/s Brassica juncea (Indian mustard) were carried out. Physiological characteristics and analysis of secondary metabolites and glucosinolate content in Cardamine hirsuta L.and Brassica juncea was done simultaneously. Physiological characteristics of Cardamine hirsuta L. with Brassica juncea.Methods were compared with the help of U.V spectrophotometer, HPTLC and qualitative chemical analysis. Since both plants belong to Brassicaceae family, mustard plant was selected to compare physical, chemical and biological properties of Cardamine hirsuta L. Their different phytoconstituents were identified and compared qualitatively as well as quantitatively. Out of many important phytoconstituent glucosinolate was further quantified simultaneously. Secondary metabolites was identified and compared qualitatively while glucosinolate content was quantified and compared. The study revealed that raw Cardamine seeds and leaves showed maximum level of glucosinolates compared to the raw mustard seeds and leaves samples. Keywords: Cardamine hirsuta L., qualitative analysis, glucosinolates. Download PDF