ARCHIVES(Journal of Harmonized Research in Pharmacy)


Title: NEW INSIGHTS IN THE FIELD OF FAST DISSOLVING TABLETS
Author: Shivangi Shukla*, Dinesh Kumar Mishra, Dinesh Kumar Jain
Keyword: Disintegration, Dissolution, Modified tablets, Novel drug delivery system (NDDS).
Page No: 213-226
Abstract: Recent advancement in drug delivery systems aims to enhance safety and toxicity of drug molecules by development of effective dosage form with improved patient compliance. In this context new approac h came in existence is a fast dissolving tablet. This is nowadays very popular dosage form as typically no water is required for the administration. Hence keeping this view in mind present article focus on ideal properties, advantages, limitation, need for formulating fast dissolving tablets, formulation factor, various technologies developed for fast dissolving tablet, patented technologies, evaluation parameters and various marketed products. Keywords: Disintegration, Dissolution, Modified tablets, Novel drug delivery system (NDDS). Download PDF


Title: REVIEW ON NON-DESTRUCTIVE QUANTIFICATION FOR SOLID DOSAGE FORMS: A NEXTGEN IN PHARMACO-ECONOMICS.
Author: Manoj Kumar Katual*, Pooja Bhardwaj, SL Harikumar
Keyword: Optical coherence tomography, Raman spectroscopy, terahertz pulsed imaging, pharmaco-economics.
Page No: 227-245
Abstract: The non-destructive techniques are now-a-days gaining popularity for the evaluation of solid dosage forms in pharmaceutical industries an alternative for the destructive techniques methods of evaluat ion. Non-Destructive techniques are advantageous over the destructive techniques. In non-destructive techniques, FTIR and IR Spectroscopy techniques are used. The research is continuing to find out a suitable alternative tool to provide the safety and efficacy of pharmaceuticals without destroying the same. It is expected to overcome the constraints related cost efficiency of pharmaceuticals sacrificed for quality control parameters. Approx. 10% of total finished products engaged in analytical process which ultimately accelerate price of final product A non-destructive evaluation of tablets is possible with the application of Fourier transform infrared spectroscopy, near-infrared spectroscopy, Optical coherence tomography (OCT) and terahertz pulsed imaging (TPI), Raman spectroscopy, and appropriate statistical techniques. The advantages of non-destructive techniques are, rapid & reproducible techniques, more precise evaluation of products (e.g. tablets, capsules etc.), less wastage of pharmaceuticals, low production cost, maintenance of dose accuracy. The new ideas about non-destructive evaluation techniques are considered to be advantageous to destructive analytical techniques and will create a new generation of safe and economic pharmaceuticals. Key words: Optical coherence tomography, Raman spectroscopy, terahertz pulsed imaging, pharmaco-economics. Download PDF


Title: FORMULATION AND EVALUATION OF CLOFAZIMINE MUCOADHESIVE SUSTAINED RELEASE TABLETS AND GEL
Author: Sunil Kumar Shah and Megha Agrawal*
Keyword: Multi-Drug-Resistance, Antituberculosis, Polyethyleneglycol, clofazimine, tablets and gel
Page No: 246-251
Abstract: Difficulty in swallowing (Dysphasia) is a common problem of all age groups, especially the elderly and pediatrics because of physiological changes associated with these groups. In this view two form ulations Mucoadhesive Gel & Mucoadhesive Tablet was prepared to prolong contact time using three different Polymers. Gel formulation was selected as it is a semisolid dosage form. The application of bioadhesive gels provides an extended retention time, adequate drug penetration, as well as high efficacy and patient acceptability. In this work two Novel formulations Mucoadhesive Gel & tablets was prepared and evaluated using three different polymers (HPMC, Carbopol, Poloxamer) using an antileprotic drug Clofazimine.Gel was prepared by simple mixing method and tablets was prepared by Direct Compression Method using Rotary Tablet Punching Machine. The tablet weight was adjusted to 500mg and 75 tablets for each batch were prepared. Keywords: Multi-Drug-Resistance, Antituberculosis, Polyethyleneglycol, clofazimine, tablets and gel Download PDF