ARCHIVES(Journal of Harmonized Research in Medical and Health Sciences)


Title: DOSIMETRIC COMPARISON OF 3DCRT VERSUS RAPIDARC IN ISO-DOSE DISTRIBUTION, DOSE VOLUME HISTOGRAM (DVH) AND DOSIMETRIC RESULTS FOR THE PTV AND CRITICAL ORGANS FOR GASTRIC CANCER
Author: Saud. H . Allehyani , Huda A. S. Sharyan and Aida R. Tolba
Keyword: Planning Tumor Volume; Organs at Risk; Conformity Index; Heterogeneity Index; Gastric cancer
Page No: 66-81
Abstract: Purpose: The aim of the present study is to compare (3D-CRT) to RapidArc planning using (LNAC of 6 MV, 15 MV and 18 MV) in terms of dosimetric outcomes of iso-dose distribution, dose volume histog ram (DVH), PTV and at risk organs in 4 patients with Gastric Cancer. Methods: Plans were created for 4 patients with Gastric Cancer who had received radical RapidArc treatment from 2012 to 2014 at KAMC (King Abdullah Medical City). Dosimetric evaluation metrics were used to compare the two plans in terms of mean, maximum and minimum doses to PTV, Homogeneity Index (HI), Conformity Index (CI), Target Coverage Index (TCI) and mean and maximum doses to critical organs and normal tissue. Dose to 95% of the PTV (D95%) was used to quantify PTV coverage. Results: RapidArc plan achieved lower mean and maximum doses to the PTV. PTV dose coverage, as measured by the minimum dose and the dose to 95% of the volume, was higher in the RapidArc plan. RapidArc plan also showed a more homogeneous dose distribution in PTV, achieving an HI of 1.1202 compared with 1.2046 in the 3D-CRT plan. However, RapidArc and 3D-CRT achieved similar CI values and improvement in TCI value. Additionally, regarding OARs, the mean and maximum dose in liver was lower in RapidArc with a low percentage of the volume receiving low doses . The mean dose to right and left kidneys were within tolerance in RapidArc and 3D-CRT. Although the mean dose was better in 3D-CRT, critical structure was better in the RapidArc plan. The mean dose to right kidney was lower in 3D-CRT, while left kidney was lower in RapidArc. For the spinal cord, the maximum dose was higher achieving 34 Gy in RapidArc, compared to 18 Gy in 3D-CRTbut within the tolerance. Therefore VMAT achieved a better mean dose to central OARs: liver, spinal cord, Kidneys and heart. Conclusions: (VMAT) is superior to 3D-CRT in term of PTV, conformity and homogeneity and accepting the VMAT class solution over 3D-CRT treatment was preferred to be determined on a case by case basis Keywords: Planning Tumor Volume; Organs at Risk; Conformity Index; Heterogeneity Index; Gastric cancer Download PDF


Title: PREVENTION OF CANCER IN HEALTHY PEOPLE
Author: Simon Skurkovich* Boris Skurkovich
Keyword: Cancer prevention, safe onco-antigen, cancer, leukemia, cancer remission, immunization
Page No: 82-86
Abstract: Cancer can be prevented in healthy people. We propose immunizing healthy people with a vaccine containing safe onco-antigens, which are antigenically similar to the oncogenic factors. As a result, he althy organism will develop robust immune response to the vaccine and will be protected against cancer. Immune components of immunized healthy relatives of cancer patients or of paid donors could also be used for adaptive therapy of these patients. Key words: Cancer prevention, safe onco-antigen, cancer, leukemia, cancer remission, immunization Download PDF


Title: BUPRENORPHINE FOR THE DETOXIFICATION OF HEROIN DEPENDENCE
Author: Jamshid Ahmadi
Keyword: Buprenorphine; Heroin withdrawals
Page No: 87-94
Abstract: Background: Heroin abuse is a considerable problem. Objective: To illuminates the efficacy of a single dose of 66 mg of sublingual buprenorphine in the treatment of heroin dependence. Results: Admini stration of a single dose of 66 mg of buprenorphine is quite effective in the treatment of heroin dependence. Discussion: Our study clarifies that administration of a single dose of 66 mg of buprenorphine is quite effective in the management of heroin withdrawal symptoms. So, the present study might be a considerable addition to the literature. Conclusion: A single dose of sublingual buprenorphine could treat heroin withdrawal symptoms and be as effective as daily buprenorphine.We concluded that, a single dose of buprenorphine is much better than traditional methods, such as sudden cessation or stepwise reduction in the heroin dosage. Key words: Buprenorphine; Heroin withdrawals Download PDF


Title: VALUE CREATING IN MEDICAL INSTITUTIONS UNDER PUBLIC-PRIVATE PARTNERSHIP: A PERSPECTIVE ON INTER-ORGANIZATIONAL GOVERNANCE
Author: Yu-Hua, Yan
Keyword: Public-private partnership, Value creating, Inter-organizational governance
Page No: 95-109
Abstract: In this liberated society and under the economic policy of privatization, adopting the “public private partnership” model not only solves the government’s financial problems, but also provides a new model for reform of public hospital administration. This thesis aims to explore and discuss the contract models of public hospitals administered by private organizations, the essence of value creation strategies and public-private partnership, connotations of governance, and the major theoretical basis. This in-depth discussion is expected to supplement the deficiency in the study of public-private partnerships in the medical industries. Finally, this research will propose recommendations targeting issues involved in public-private partnerships and a direction for future researches. Key Words: Public-private partnership, Value creating, Inter-organizational governance Download PDF


Title: PROFILE OF OTORHINOLARYNGOLOGICAL MORBIDITY IMPACTING HEARING FUNCTION IN SCHOOL CHILDREN AT TERTIARY CARE CENTRE
Author: Deepti Pandey
Keyword: Hearing loss; Otologic disorder; Hearing loss
Page No: 110-112
Abstract: Prevention of hearing loss is crucial in school children to guard them against failure of academic and social development. The common threats that may be preventable and modifiable need be known ther efore. 134 school age patients visiting ENT outdoor with some ear complaint and profiled to generate local evidence base. Hearing impairment was there in 27.6% of school age patients with ear complaints. Ear wax impaction was most common external ear disease but middle ear diseases were most causal to hearing loss which was essentially of conductive type. Ample scope of timely detection and intervention for prevention of hearing loss existing in school age children .Expansion of care facilities and appropriate health education for seeking care. Keywords: Hearing loss; Otologic disorder; Hearing loss Download PDF


Title: MONITORING OF VARIATIONS IN SOME HEMATOLOGICAL PARAMETERS AND LIVER ENZYMES AS A RESULT OF EXPOSURE TO 50-HZ ELECTRIC FIELDS
Author: A. M. Khalil, Ahmed. M. El-Khatib, Moustafa M. Mohamed, Mostafa El-Khatib, Hanan.M.Abdulsalam, Gamal D Roston
Keyword: Electric field, RBCs, hematology, CBC, Liver
Page No: 113-120
Abstract: Monitoring of relative variations in some hematological parameters and liver enzymes for albino rats due to 50Hz-4kV/m electric field exposures at different exposure periods is studied. Six groups of animals are used; group A considered as sham group that housed at normal environmental conditions and didn’t receive any treatments. The other five groups B, C, D, E and F exposed to electric fields for different exposure periods 5, 10, 15, 20, 30 days respectively. Blood samples are collected immediately after sacrificing from each animal and complete blood count CBC and liver enzymes are examined. The results of RBCs evaluations of exposed groups indicated slight decrease but highly correlated to exposure time. Whereas, the data of WBCs evaluations showed insignificant and uncorrelated variations compared to unexposed group A. The liver enzymes (SGOT, SGPT) data figured increasing and highly correlation to exposure times compared to group A. In conclusion, exposure to ELF EMF is ambiguous and has subtle hazardous effect and the need of future works to elucidate any health consequences may be attributed to the exposure of such fields. Key words: Electric field, RBCs, hematology, CBC, Liver Download PDF


Title: AN INTEGRATED APPROACH OF RESEARCH THROUGH YOGA, NATUROPATHY, HEALING AND PHYSIOTHERAPY IN REDUCING PAIN AND IMPROVING FUNCTIONAL STATUS OF OSTEOARTHRITIS PATIENTS IN EFFICIENTLY AND SAFELY.
Author: Dr. Anath Bandhu Mondal, Dr. Kiran Shankar Chatterjee, Dr. Rzual Islam, Dr. Nilkamal Mallik, Dr. Dipak Mondal, Sajal samanta, Prasanata Jana, Sanath Takhur
Keyword: Osteoarthritis of Knees, Yoga, Naturopathy, Physiotherapy, Healing
Page No: 121-130
Abstract: Osteoarthritis of Knees (OA Knees) also known as degenerative arthritis or degenerative joint disease is a group of mechanical abnormalities involving degradation of joints, including particular cart ilage and subchondral bone. The aim of the study focuses on reduction of symptoms and increase in functional activities of elderly patients with osteoarthritis of knees before and after modalities of yoga, naturopathy and physiotherapy. A total 53 patients were recruited .All human participants were treated on Yoga, Healing, Naturopathy, Physiotherapy and diet control. The study parameters were assessed at baseline and at 12th month follow-up. Results found in this study shows an improvement in pain, 50 foot walk test, morning stiffness, swelling, SF-12, Vitamin D3 level, MMT and ROM after taking one year Yoga, Naturopathy and Physiotherapy Healing treatment with diet control . In conclusion, a combined package of Yoga, Naturopathy and Physiotherapy with diet control is found to be effective in reducing pain, facilitating improvement in functional status of elderly people suffering from Osteoarthritis of Knees. Keywords: Osteoarthritis of Knees, Yoga, Naturopathy, Physiotherapy, Healing Download PDF


Title: AN UPDATE ON CAUSTIC GASTROINTESTINAL INJURY WITH MINIMALLY INVASIVE TREATMENT OPTIONS
Author: David M. Schwartzberg, Sathyaprasad C. Burjonrappa, Paresh C. Shah
Keyword: Gastrointestinal tract, cytotoxic agents, Endoscopy and laparoscopy
Page No: 131-141
Abstract: Caustic injury of the gastrointestinal tract (GI) has remained a costly and devastating problem to the bi-modal population affected, however it has seen encouraging evolutions in its care. Caustic i njury is defined as an ingested acid or base that results in a wide range of pathology in the upper GI tract, mainly the upper airway, esophagus and stomach. To yield an update on caustic injuries with succinct recent innovations in care, previously published articles, with an emphasis on more recent articles were searched for using Pubmed and MEDLINE. Major advancements in technology have improved the treatment of the acute phase of injury leading to a more uniform methodology in diagnosis, less morbid acute temporizing measures and improved staging of acute injury with the help of advancements in computed tomography and endoscopic interventions. With the advancement of endoscopy and laparoscopy, acute treatment and chronic complications of caustic injury have been reassuringly improved. Endoscopy and laparoscopy have also aided in therapeutic advancements with the implementation of endoscopic dilation of strictures and minimally invasive techniques for gastro esophageal bypasses and resections. Emerging are biochemical platforms such as bioscaffolds to promote esophageal healing and topical anti-cytotoxic agents to treat esophageal strictures. Treating caustic injury has seen recent advancements with the aid of minimally invasive diagnostic and therapeutic modalities to help in the acute and chronic phases of care as improvements in clinical outcomes with novel biocellular techniques emerging. Key Words: Gastrointestinal tract, cytotoxic agents, Endoscopy and laparoscopy Download PDF


Title: A CASE OF SYMMETRIC PERIPHERAL GANGRENE
Author: Dr. Henna Naqash and Dr. Fayaz Wani
Keyword: Gangrene , Vasculitis , Smoking
Page No: 142-148
Abstract: A 50 – year old male, farmer, presented with complaints of abnormal sensations, pain and discoloration of hands & feet for last 7 months. He was a tobacco smoker with 15 pack – years of smoking. He h ad tachycardia, asynchronous pulses, dry purplish black toes, fingers and parts of adjacent hands and feet on examination. Investigations revealed leucocytosis, high ESR and protein S deficiency. Keywords: Gangrene , Vasculitis , Smoking. Download PDF


Title: A STUDY TO ASSESS THE LEVEL OF KNOWLEDGE REGARDING EBOLA VIRUS INFECTION AND ITS PREVENTION AMONG MEDICAL AND NURSING STUDENTS OF TEERTHANKER MAHAVEER UNIVERSITY MORADABAD
Author: Garba Adamu, N. V. Muninarayanappa, Nageswar V, Prabhu J.
Keyword: Ebola, knowledge, infection, prevention
Page No: 149-152
Abstract: This study was conducted to assess the level of knowledge regarding Ebola virus infection and its prevention among medical and nursing students of Teerthanker Mahaveer University Moradabad. The main aim of the study was to assess the level of knowledge about Ebola infection and compare the knowledge level between Medical and Nursing students. A quantitative research approach was adopted and sample was drawn from third year students from the respective colleges. Structured questionnaire was used to collect data from the study population and it entailed information about Ebola disease. Collected data were analyzed using descriptive and inferential statistics. Knowledge level score was tabulated by mean and comparisons in knowledge level were known using standard deviation and unpaired T. test. Association was measure using chi-square test. The study revealed that, 39.2% have inadequate knowledge, 60.8% have moderate knowledge and none have adequate knowledge regarding Ebola virus infection. The different in knowledge revealed that, Medical students have a mean score of 12.74 with standard deviation of 3.345, while Nursing students have mean score of 11.19 and standard deviation of 2.363. The mean different in knowledge level is 1.56. Keywords: Ebola, knowledge, infection, prevention Download PDF