ARCHIVES(Journal of Harmonized Research in Pharmacy)


Title: PROCESS OF PLANNING FOR MEDICAL EQUIPMENT
Author: Srijita Dutta
Keyword: Computer system, medical equipment, program.
Page No: 83-85
Abstract: This paper presents a computer system for assisting the health care services planning and the acquisition process of medical equipment. After choosing one of the health services listed on screen, the computer system presents a second list of essential and secondary equipment for that specific service. To specify chosen equipment from that second list, the user has to answer a series of predetermined questions that are also displayed on screen. At the end of the questionnaire, the program generates a report containing the equipment characteristics defined by the user for its acquisition. All those questions were defined for given equipment based on data describing its own characteristics. The user is able to modify the predetermined questions to adjust them for a specific type of equipment. The answers, given by the users, are then stored by the system and presented every time a new specification for that type of equipment is made. Keywords: Computer system, medical equipment, program. Download PDF


Title: STANDARDIZATION OF SOME BIOACTIVES IN GINGER EXTRACT
Author: Namita Sagar Girhepunje and Dr S.K.Tilloo
Keyword: Ginger, gingerol, standardization, antibacterial
Page No: 86-94
Abstract: The aim of the present study was to estimate the bioactives from some marketed preparations of ginger especially with reference to gingerol and to compare with active constituents present in crude dr ug and estimation of the gingerol contents with the help of different analytical techniques like TLC, IR and UV spectrphotometry also evaluation of antibacterial activity of the marketed ginger preparations and to correlate it with gingerol contents. From the study, it was observed that the range of gingerol is from 90.08% to 104.92%w/w., which was found to be fairly compliant with the I.P. specifications i.e.90-120% w/w. These differences in the range of gingerol content suggest that there must be different exogenous and endogenous factors affecting the quality and purity of the drug, it is very essential, being vital and important. Due to this reason the need was generated for the pharmacological, phytochemical evaluation and standardization of various formulations available in the market. The present study was extended for determination of antibacterial property by cup plate method by taking Ofloxacine as a Standard.The sample of Green Pharmacy indicated that there was high antibacterial property. Hence from the result it was clear that presence of high amount of gingerol in ethanol extract (Green Pharmacy) Key words:-Ginger, gingerol, standardization, antibacterial Download PDF


Title: ANTIMICROBIAL AND ANTIOXIDANT PROPERTIES OF GREWIA UMBELLIFERA
Author: Vijay Thirugnanasambandan*, Sarumathy Kannayiram
Keyword: Grewia umbelliferea, Phytochemical, Antioxidant and Antimicrobial activity
Page No: 95-106
Abstract: Objective: To investigate phytochemical properties, free radical scavenging and antimicrobial activity of medicinal plant Grewia umbelliferea fruit and root extracts. Methods: Dried, powdered fruit and root were extracted by Soxhlet apparatus with successive solvent extraction method. The filtrates were used for preliminary phytochemical analysis, radical scavenging assays (DPPH, ABTS and FRAP) and antimicrobial studies (Agar well diffusion method). Results: Preliminary phytochemical analysis clearly confirmed the Grewia umbelliferea fruit contains of phenolics, tannin and flavonoids. Acetone extract of fruit showed significant antioxidant scavenging activity in DPPH (20.0 µg/ml), ABTS (41343.51 µM TE/g extract) and FRAP (4713.33 mM Fe (II)/mg extract) assays. Acetone extract of fruit indicated highest inhibitory activity (IZ 22.6 mm) against K. pneumonia at 200 mg/mL. The lowest inhibitory activity (IZ 2.0 mm / 100mg/mL) against bacterial species were showed by hot water extract of root against S. pneumoniae. Except the hot water extract all other extracts were resist the Aspergillus sp at different inhibitory zone levels from 0.5 to 14.0 mm which depends upon their concentration. Conclusion: The acetone extract of Grewia umbelliferea fruit and root has revealed the presence chemical compounds which are responsible for its antioxidant and antimicrobial activity. Keywords: Grewia umbelliferea, Phytochemical, Antioxidant and Antimicrobial activity Download PDF


Title: METHADONE IN THE TREATMENT OF METHAMPHETAMINE WITHDRAWAL SYMPTOMS
Author: Jamshid Ahmadi
Keyword: Methadone; Methamphetamine withdrawals.
Page No: 107-115
Abstract: Background: Methamphetamine dependence is considered an advancing problem. Objective: To demonstrate the function of methadone in the management of methamphetamine withdrawal symptoms. Results: 40 m g of methadone per day is profit making in the treatment of methamphetamine withdrawal symptoms. Discussion: This study demonstrates that methadone 40 mg/d is effective in the reduction and cessation of methamphetamine withdrawal symptoms. So, our finding is a substantial addition to the literature. Conclusions: Methadone is a satisfactory medication for the treatment of methamphetamine withdrawal symptoms. Continued study of methadone administration, is highly recommended for the management of methamphetamine dependence. Key words: Methadone; Methamphetamine withdrawals. Download PDF


Title: MESOPOROUS SILICA SOLID DISPERSION CARRIER SYSTEMFOR SCANTY WATER SOLUBLE DRUG TO ESTABLISH CLINICAL DOSAGE FORMS
Author: P Ambedkar* and Dr.E Harikrishna
Keyword: Itraconazole, mesoporous silica, solubility, solid dispersions and gelucire
Page No: 116-121
Abstract: Mesoporous MCM-41 is one of the mesoporous materials, used now-a-days as drug carrier. Itraconazole (ICZ) is a highly hydrophobic, BCS System class II drug.ICZ on oral administration results in poor bioavailability and inters individual variations in plasma drug concentrations due to poor aqueous solubility. Proximate target of the present study is to ameliorate the dissolution and bioavailability of Itraconazole by formulating the solid dispersions using mesoporous material as a carrier (MCM-41). Itraconazolesolid dispersions were prepared by solvent evaporation method polyethylene glycol-4000, 6000, polaxomer-407, HPMC, Gelucire 50/13, Gelucire 44/14, and mesoporous silica (MCM-41), among all the carriers mesoporous silica has delineated good results and exhibited dissolution enhancement confronts with the Itraconazole plain drug and marketed product. Stability was performed according to the ICH guidelines, accelerated, intermediate, and long term in stability results clearly demonstrated that mesoporous silica solid dispersions were stable. Key Words: Itraconazole, mesoporous silica, solubility, solid dispersions and gelucire Download PDF