ARCHIVES(Journal of Harmonized Research in Pharmacy)


Title: EFFECTIVE FU LING (PORIACOCOS) FOR THE TREATMENT OF OBESITY?
Author: Dr. Luis Carlos Mendes
Keyword: Obesity, Orlistat, Poria-cocos, Anti obesity drugs, Coronary Artery Disease
Page No: 183-192
Abstract: Obesity is a chronic disease that currently constitutes one of the major health problems of modern societies. In recent decades there has been an increase in the average weight of the population, as well as the prevalence of the number of obese individuals.(5-10) Obesity is associated with an increased prevalence of diabetes, hypertension, dyslipidaemia, hyperuricaemia, and gallbladder lithiasis. Waist circumference is now considered one of the main factors for the diagnosis of metabolic syndrome. According to the latest classification proposed by the International Diabetes Federation in 2006 (12)are diagnostic criteria circumference of the upper waist 94cm for European and 80cm men for European women, triglycerides greater than 150mg / dl, HDL < 40 mg / dl for men and 50 mg / dl for women, systolic blood pressure> 130 mmHg or diastolic blood pressure> 85 mmHg and fasting plasma glucose> 100 mg / dl. Obese patients are often a dyslipidemia characterized by hypertriglyceridemia, lowering cholesterol and increased HDL LDL. This metabolic profile is present the most often in obese patients with accumulation of intra-abdominal fat, which has been associated with increased risk of ischemic heart disease (IHD). (1) It is estimated that, in Europe, the prevalence of obesity is 10-25% in most countries(1), in the US of 30.5% (2)and in Portugal have 38.6% of adults overweight and 13.8% are obese(3). In addition, also the alarming increase of overweight and obesity in the young in our country(4), seem to justify launching projects aimed at better understanding of these diseases and the promotion of measures aimed at combating it. The XENDOS (15)is the largest study to date with a drug for weight loss. Among the various studies which demonstrate a reduction in weight, the more effective is the Orlistat at a rate of 30% in the prevention of absorption of fat ingested at a dose of 120 mg three times a day.(13-14) Thus, this study will seek to verify whether it is really effective use of PoriaCocos in obesity compared with Orlistat. Keywords: Obesity, Orlistat, Poria-cocos, Anti obesity drugs, Coronary Artery Disease Download PDF


Title: DEVELOPMENT AND VALIDATION OF NEW ANALYTICAL METHODS FOR THE ESTIMATION OF ASPIRIN AND ATORVASTATIN CALCIUM BY RP- HPLC METHOD
Author: V. Subash Chandra Boss*, E.Priyanka, R.Radhika, S.Ranjitha, S. Selvanayagi
Keyword: Development and new validation, Atorvastatin calcium, Aspirin, Capsule form and RP HPLC.
Page No: 193-200
Abstract: A new simple, specific, precise and accurate revere phase liquid chromatography method has been developed for estimation of atorvastatin calcium (AST) and ASPIRIN (ASP) simultaneously in a combined c apsule dosage forms. The chromatographic separation was achieved on a 5 – micron C 18 column (250x 4.6mm) using a mobile phase consisting of a mixture of Orthophosphoric acid buffer: Acetonitrile (45:55) was used pH 4.5. The flow rate was maintained at 1.0 ml / min. The detection of the constituents was done using UV detector at 237 nm for AST and ASP. The retention time of ASP and AST were found be 3.8 min and 9.4 min respectively. The developed method was validated for accuracy, linearity, precision, limit of detection (LOD) and limit of quantification (LOQ) and robustness as per the ICH guidelines. Key words: Development and new validation, Atorvastatin calcium, Aspirin, Capsule form and RP HPLC. Download PDF


Title: TO STUDY THE EFFICACY OF NITRIC ACID, RATAHNIA, AESCULUS, HAMAMELIS, SULPHUR & NUX VOMICA IN MANAGEMENT OF HAEMORRHOIDS
Author: Dr. Parth Aphale*, Dr. Atul Rajgurav
Keyword: Haemorrhoids, Bleeding, Thrombosed.
Page No: 201-210
Abstract: Background: Hemorrhoids are very common. Nearly three out of four adults will have haemorrhoids from time to time. Sometimes they don't cause symptoms but at other times they cause itching, discomfor t and bleeding. Occasionally, a clot may form in a hemorrhoid (thrombosedhemorrhoid). These are not dangerous but can be extremely painful and sometimes need to be lanced and drained. Fortunately, many effective options are available to treat hemorrhoids. Many people can get relief from symptoms with homoeopathic treatment and lifestyle changes. Methods: 30 cases of haemorrhoids were studied satisfying the case definition. Inclusion and exclusion criteria were laid down. Assessment Criteria was laid down. Results: Observations with respect to age, sex, occupation, remedies was done and efficacy of Homoeopathy was analysed in these cases. Conclusion: Homoeopathy is useful in treating cases of haemorrhoids. Keywords: Haemorrhoids, Bleeding, Thrombosed. Download PDF


Title: FORMULATION AND CHARACTERIZATION OF SUGAR FREE FAST DISSOLVING ANTIALLERGIC TABLET
Author: Divya Pathak*, Md. Semimul Akhtar
Keyword: Levocetirizine dihydrochloride, Direct compression, superdisintegrant, INVITRO dissolution, anti allergic tablet, Formulations.
Page No: 211-223
Abstract: Allergic disorders are most common worldwide. It also affects the quality of life. Due to these reasons, there is a requirement to develop rapid action producing formulation to treat these allergic conditions. Purpose- The Purpose of the study was Formulation and characterization of sugar free fast dissolving anti allergic tablet. Method- Formulation was done by using direct compression method with the aid of Super disintegrants addition. Twelve formulations were developed using three different super disintegrants in varying concentrations in such a way that total weight of the tablet remains the same. Results- Based on the results, formulation (PF-9) containing 2% Ac di sol and 5% Polyplasdone XL-10 was identified as ideal and best formulation among all formulations. In vitro release of optimized formulation (PF-9) was found to be 98.80% and drug release within 10 min and in vitro dispersion time was found to be 25sec. Conclusion- Levocetirizine Dihydrochloride was successfully formulated by direct compression method the tablets were evaluated for Pre-compression parameters. As a result, this introduced the good flow and compressibility property of the bulk powder. Post compression parameters such as Physical parameter and chemical parameter was performed on punched tablets and found all the parameters within limit specified by Indian Pharmacopoeia. Keywords: Levocetirizine dihydrochloride, Direct compression, superdisintegrant, INVITRO dissolution, anti allergic tablet, Formulations. Download PDF


Title: BIODEGRADABLE MICROSPHERES FOR SUSTAINED RELEASE DELIVERY OF REPAGLINIDE
Author: Engla G., Soni L.K. and Dixit V.K.
Keyword: Biodegradable, Microspheres, Poly(lactic-co-glycolic acid) (PLGA), Repaglinide, Surface Electron Microscopy (SEM) and Fourier’s Transformation Infra Red Spectroscopy (FT-IR).
Page No: 224-229
Abstract: The objective of the present study is to prepare repaglinide microspheres for the sustained delivery of the drug for better patient care in the management of diabetics. The biodegradable microspheres of repaglinide is prepare using poly(lactic-co-glycolic acid) (PLGA) by emulsion solvent evaporation technique. The microspheres are prepared with different drug-to-carrier ratios and considering other variables (i.e. solvent, surfactant and stirrer speed) as well. The evaluation of microspheres prepared are perform on the basis of various parameters like particle size, percentage yield, drug entrapment efficiency, surface morphology (SEM), drug-polymer interaction (FT-IR study), in vitro drug release kinetics and stability studies. SEM reveals that microspheres are spherical and has nearly smooth surface morphology. The percentage yield and drug entrapment efficiency is quite well for all the formulations. FT-IR spectra show that there is no chemical interaction between the drug and the polymer. The in vitro release study data shows that the repaglinide release from all the formulations are slow and sustained upto 7days. The various kinetic equations indicate that the in vitro drug release is of zero order release with initial burst from repaglinide microspheres. There is no appreciable difference is observed in the stability study observations. Key words: Biodegradable, Microspheres, Poly(lactic-co-glycolic acid) (PLGA), Repaglinide, Surface Electron Microscopy (SEM) and Fourier’s Transformation Infra Red Spectroscopy (FT-IR). Download PDF


Title: IN VITROANTIOXIDANT ACTIVITIES OF PHYLLANTHUSAMARUS HERBS
Author: Om Prakash Agrawal*, Girendra Gautam
Keyword: Phyllanthus amarus, Antioxidant, DPPH, Hydroxyl Ion.
Page No: 230-236
Abstract: In this study, measure antioxidant potential of P. amarus by DPPH radical scavenging activity, Superoxide radical scavenging activity and Hydroxyl radical scavenging activity method using ether, aque ous and ethanol extract in different propagation also reference compound as Ascorbic Acid. In DPPH radical scavenging activity, ethanol extract show higher percentage inhibition 93.50% at 250µg/mL. Higher percentage inhibition of all three activities i.e. DPPH, SOD and hydroxyl at 250 µg/mL by ethanol extract is 96.50 % with reference compound i.e. Ascorbic Acid-97.00%. Keywords: - Phyllanthus amarus, Antioxidant, DPPH, Hydroxyl Ion. Download PDF