ARCHIVES(Journal of Harmonized Research in Pharmacy)


Title: EVALUATION OF ANTIHYPERTENSIVE AND ANTIGLAUCOMA ACTIVITY OF ANDROGRAPHIS PANICULATA AND ACACIA ARABICA USING RAT ANIMAL MODEL
Author: Md. Salahuddin Ansari* and Pankaj Sharma
Keyword: Andrographis paniculata, Acacia Arabica, Hypertension, Glaucoma
Page No: 24-28
Abstract: Cardiovascular diseases are the leading cause of death globally. The medicinal value of plants lies in some chemical substances that produce a definite physiological action on the human body. Androgr aphis paniculata is used traditionally as a remedy against common cold, dysentery, cardiovascular disease and Acacia arabica is used for the treatment of asthma, cough, and ophthalmic. Hypertension induced by adding 1-2 % NaCl to drinking water for 3-6 months and injecting Deoxycorticosterone acetate-induced (10 mg/kg). Glaucoma is induced in rabbits by intraocular injection of alpha-chymotrypsin. Male rabbits weighing about 2 kg will be pretreated with 10 mg/kg i.p. indomethacin to prevent the otherwise immediate onset of inflammation and then slightly anesthetized with pentobarbital to eliminate any nystagmus. The right eye is anesthetized topically with 2% lidocaine. The interesting fact is that low dose combination of AP and AEP in highly effecting in decreasing MABP but neither High dose AP nor High dose AEP alone was achieved highest Decrease in MABP. The diabetic rats treated with the EEME (250mg/kg) showed a significant (p<0.05) reduction in fasting serum glucose level as compared to 0 day after 7th, 14th and 21st day treatment. The fall in serum glucose level was gradual and consistent. Keywords: Andrographis paniculata, Acacia Arabica, Hypertension, Glaucoma Download PDF


Title: PHARMACOGNOSTIC AND PHYTOCHEMICAL INVESTIGATION OF NELUMBO NUCIFERA LEAVES
Author: Shikha Sharma, Shailendra Lariya, Sunil Mistry
Keyword: Nelumbo nucifera, Macroscopy, Microscopy, Phytochemical Screening.
Page No: 29-34
Abstract: Nelumbo nucifera Gaertn. is a monogeneric plant belongs to family Nelumbonaceae, commonly known as sacred Indian lotus, rose of India, sacred water lily or East Indian lotus. It has been used through out Egypt, the Middle East, India, and China since ancient times, primarily as a food, but also as a medicine. The present study was carried out to evaluate the Pharmacognostic and qualitative analysis of various phytochemicals parameters of Nelumbo nucifera leaves. Keywords: Nelumbo nucifera, Macroscopy, Microscopy, Phytochemical Screening.Download PDF


Title: ANTIDIABETIC POTENTIAL OF ALCOHOLIC EXTRACT OF ANNONA SQUAMOSA LINN. BARK IN NORMAL AND ALLOXAN INDUCED DIABETIC RATS
Author: Sandeep and Abilasha Mittal
Keyword: Annona squamosa, antidiabetic, herbal remedy, sareefa,
Page No: 35-40
Abstract: The present investigation aims to examine the diabetic potential of the plant sareefa in normal and alloxan induces diabetic rats. The barks were successively macerated with Pet. Ether (60-80), chlor oform, ethyl acetate, ethanol and water. The ethanolic extract showing the more potent chemical screening results were selected and prepared through Maceration. Alcoholic extract of bark of Annona squamosa at dose of 300 mg/Kg was given to normal and alloxan induced diabetic rats and blood samples taken from the retero-orbital plexus vein were analyzed for blood glucose level as per standard protocol with available haemoglucostrips of TOUCH blood glucometer. The comparison of blood sugar levels as per model schedule shows that in normal group the ethanolic extract, at a dose of 300 mg/Kg intra-peritoneal, the blood glucose lowering was shown which conclude, the ethanolic extract of Annona squamosa reflected anti-diabetic potential through its glucose lowering activity in experimental animals. It supported the folklore claim of anti-dibetic activity of plant. Keywords: Annona squamosa, antidiabetic, herbal remedy, sareefa, Download PDF