ARCHIVES(Journal of Harmonized Research in Pharmacy)


Title: EVALUATION OF ANTICONVULSANT ACTIVITY OF LEAF EXTRACTS OF SECURINEGA LEUCOPYRUS IN SWISS ALBINO MICE
Author: S. Amreen Sultana*, A. Laly Steven, B. Mounica, N. Rama Lakshmi, D. Eswar Tony, N. Rama Rao
Keyword: Securinega leucopyrus, Anti convulsant, Strychnine, Mice, Seizure
Page No: 41-45
Abstract: Objective: In the present study Anti convulsant activity of Methanolic and aqueous extracts of leaves of Securinega leucopyrus were evaluated.Materials & Methods: Anti convulsant activity of Methanol ic and Aqueous extracts of leaves of Securinega leucopyrus were evaluated by Strychnine-induced seizure in mice. The Methanolic and Aqueous extracts of leaves of Securinega leucopyrus (200mg/kg) treat the convulsions and produced significant reductions in severity and frequency of seizures. Standard drug Diazepam (2mg/kg, i.p) has shown significant reduction in frequency of seizures whereas methanolic extract of leaves of Securinega leucopyrus (MESL) and aqueous extract of leaves of Securinega leucopyrus (AESL) at a dose of 200 mg/kg, oral significantly (P<0.05) reduced frequency of Strychnine induced convulsion.Conclusion: Both MESL and AESL showed marked reductionin the frequency of seizuresbut the efficiency of MESL is more when compared to AESL. The results suggest that the MESL and AESL have the ability to control the extent and severity of seizures in mice. Keywords: Securinega leucopyrus, Anti convulsant, Strychnine, Mice, Seizure Download PDF


Title: ACUTE INTOXICATION BY SYNTHETIC CANNABINOIDS: CLINICAL AND LABORATORY FINDINGS: A CASE SERIES
Author: Ali Cem Yekdes*
Keyword: Synthetic cannabinoids, intoxication, psychoactive.
Page No: 46-50
Abstract: New psychoactive products (synthetic cannabinoids) which are subgroups of the cannabinoids began to be produced after prohibition and reduced accessibility of other cannabis in many countries. This p sychoactive molecules act as an agonist of cannabinoid 1-2 receptors (CB1-2) resident central and peripheral nervous system. Many psychiatric symptoms such as euphoria, anxiety, agitation, irritability, paranoia, psychosis can be seen also physical symptoms like sweating, nausea, vomiting, appetite changes, hypertension, hypotension, chest pain, tachycardia, bradycardia, and respiratory depression can be seen. In our study we aimed to discuss clinical conditions of the cases which were brought to Emergency service(ER) with cannabinoid intoxication diagnosis after that followed up in intensive care unit (ICU). Materials and Methods: 25 patients with synthetic cannabinoid intoxication enrolled into the study between 2015-2016. Age, sex, neurological and cardiac examination during time of application, laboratory values such as pH, urea, creatinine, white blood cell counts, electrolyte levels, liver function tests were evaluated and statistically risk analysis was performed for each parameter. Results: The number of patients with synthetic cannabinoid intoxication was 25. Female/male ratio was 1/24. Ages of the cases were changes between 19 to 59, mean age was 26, 1. In neurological examination in ER 8 patients(%32) had unconsciousness, 2 patients(%8) had agitation, 5 patients(%20) had confusion, 8 patients(%32) had dizziness. 2 patients were normal for neurological examination, Glasgow coma scale were 15. In examination cardiological findings were 5 cases (%20) only tachycardia, one case (%4) hypertension, 10 cases (%40) hypotension and tachycardia together. Cardiological examinations were normal in 9 cases (%36). None of cases had bradycardia or other arrhythmic situations. In gastroenterologic examination we did not find nausea, vomiting or other gastroenterologic symptoms. 4 patients (%16) were followed up in ICU more than 48 hours. 4 patients (%16) were discharged from ICU less than 24 hours. Other 17 patients (%68) were followed up at least 24 hours that must be. Death did not occur in our cases. Conclusion: Synthetic cannabinoids square measure unsafe and harmful medicine of abuse; they'll even cause severe side effects. There's a necessity for a multidisciplinary approach for recognition and treatment of the clinical manifestation ensuing from synthetic cannabinoid use. Education of teachers, parents and adolescents about the potential health risks of victimization this product is important. Key words: Synthetic cannabinoids, intoxication, psychoactive. Download PDF


Title: MEDICINAL & ECOLOGICAL POTENTIAL OF KASERU (SCIRPUS GROSSUS): A REVIEW
Author: Dr. Lalit Raj Singh
Keyword: Phytoremediation, GACP, Sustainable, Phytoconstituents
Page No: 51-53
Abstract: Aim of this study was to review the efficiency of plant in curing various disorders/disease along with phytoremediating potential of the plant. Microbes associated in their rhizospher e help in biodegradation of hydrocarbons and removal of metals and heavy metals from water and soil. Ethnomedicinal uses of the plants help in curing various disorder/disease in human. Phytoconstituents percentage, safety, Purity, strength and therapeutic index of the GACP plants is higher. Keywords: Phytoremediation, GACP, Sustainable, Phytoconstituents Download PDF


Title: STUDY OF ANTIMICROBIAL ACTIVITY OF 2-METHOXY-6-{[2-(2-METHOXY-PHENOXY)-ETHYLIMINO]-METHYL}-PHENOL AND ITS TRANSITION METAL COMPLEXES ON E.COLI AND STAPHYLOCOCCUS AUREUS.
Author: Sheetal. V. Palande* and Dr. Deelip K. Swamy
Keyword: Schiff bases, Metal Complexes, Spectral analysis, Antimicrobial activity
Page No: 54-59
Abstract: Coordination complexes of transition metals with Schiff base ligands were synthesized. The characterization of these compounds were carried out by physical parameters and spectral analysis namely col or, melting point, IR, NMR, UV, Magnetic measurements, TGA and ESR studies. The spectral analyses are used for elucidating the structure of ligand and metal complexes. Biological activity of the compounds has been studied for bacteria E. coli and Staphylococcus aureus. Keywords: Schiff bases, Metal Complexes, Spectral analysis, Antimicrobial activity. Download PDF