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Title: PROPOSE ONE ADDED SCHEME IN ADDITION TO LASSO ALONG WITH RIDGE
Author: Mrs. Rajmati, Mr. Rakesh Tiwari, Mr. Shivendra Dubey Mr. Mukesh Dixit
Keyword: Regression, Lasso, Ridge, SVM, and KNN
Page No: 38-45
DOI: 10.30876/JOHR.6.4.2018.38-45
Abstract: Regression analysis is an important tool for modeling and analyzing data. Here, we fit a curve / line to the data points, in such a manner that the differences between the distances of data points fro m the curve or line is minimized. As given in our paper their there is comparing between Lasso and Ridge, In our work we will introduced one more method and show their comparison, so before implementation let’s see some of the factors which are involve during this research. Keyword- Regression, Lasso, Ridge, SVM, and KNN Download PDF


Title: ONE-FACTOR-AT-A-TIME (OFAT) OPTIMIZATION OF ?-GALACTOSIDASE PRODUCTION FROM ASPERGILLUS FLAVUS GR. NFCCI-2728 IN SUBMERGED FERMENTATION.
Author: J. D. Patel*, B. V. Raol, N. H. Bhavsar and G. G. Raol*
Keyword: Aspergillus flavus, OFAT, Submerged fermentation, Czapek’s-Lactose broth.
Page No: 227-235
DOI: 10.30876/JOHR.6.4.2018.227-235
Abstract: Production of ß-galactosidase enzyme under submerged fermentation was carried out using Aspergillus flavus gr. NFCCI-2728. Optimization of different cultural conditions viz., incubation time, nitrogen source and its concentration, carbon source and its concentration, pH and inoculum size were carried out using one factor at time approach (OFAT) in Czapek’s-Lactose (CL) Medium for enhanced production of ß-galactosidase enzyme. The highest yield of ß-galactosidase was achieved 843.75 Umg-1 which was 4.75 times higher than unoptimized medium. Keywords: Aspergillus flavus, OFAT, Submerged fermentation, Czapek’s-Lactose broth. Download PDF


Title: APPLICATIONS OF LINEAR ALGEBRA IN GENETICS
Author: M. Naga Maruthi Kumari, Kavya.H.U and Krupashree .Y.N
Keyword: Eigen values, Eigen vectors, Diagonalization, Autosomal inheritance, Genotype, genotype distribution.
Page No: 236-240
DOI: 10.30876/JOHR.6.4.2018.236-240
Abstract: The present paper is focusing on the Mathematical concepts from Linear Algebra including Eigen values and eigen vectors and disgonalization to predict the genotype distribution. This paper is based on finding the genotype distribution for nth generation in Autosomal inheritance. Key Words: Eigen values, Eigen vectors, Diagonalization, Autosomal inheritance, Genotype, genotype distribution. Download PDF


Title: A MEASURE OF YOGA PERSONAL OBSERVANCE (NIYAMA): A CONFIRMATORY FACTOR ANALYSIS
Author: Sadhna Dadhore, G. Paran Gowda
Keyword: Yoga, Personal observance or niyama, Personality, Scale development.
Page No: 241-253
DOI: 10.30876/JOHR.6.4.2018.241-253
Abstract: The background idea on yoga personal observance is given in the form of an aphorism in astanga yoga (eight limbed yoga). The concept on yoga personal observance scale (YPOS) is developed based on yoga books. The purpose of this paper is to develop a yoga personal observance scale using confirmatory factor analysis. A psychometric analysis of cronbach alpha, validity, reliability, correlation factor loadings, factor extraction from a uni-diagonal matrix, reduced items, fitness indices etc. We used SPSS and AMOS version 25 exploratory and confirmatory factor analyses to develop YPOS. To test the scale, we randomly selected 1,304 participants from general populations of Bhopal city, India. The developed 28-item five factor YPOS comprised standardized regression coefficients with 58.46% variance with a Cronbach’s alpha of 0.76. The results of three different model Fitness categories of indexes with construct, convergent, concurrent validity were also analyzed and found to be acceptable. There is a scope for further research development in each of the eight limbed yoga practices. Keywords: Yoga, Personal observance or niyama, Personality, Scale development. Download PDF


Title: ANALYTICAL METHOD DEVELOPMENT AND VALIDATION BY HEADSPAVE GAS CHROMATOGRAPHY FOR RESIDUAL SOLVENTS IN IGURATIMOD
Author: Ravindra B. Nehete, Pushpendra Sharma
Keyword: Iguratimod, validation, development.
Page No: 254-264
DOI: 10.30876/JOHR.6.4.2018.254-264
Abstract: Testing of residual solvent is a primary requirement for any drug substance. These studies provide information about the residual solvents content in Iguratimod with simple, accurate, precise by heads pace gas chromatography. Method by head space gas chromatography with flame ionization detector has been developed and validated to detect and quantitate the specified solvents. Baseline separation in-between the peaks were been achieved by suing capillary column with a flame ionization detector. Percentage recovery obtained in the range of 80-120% and the method is linear for all the specified solvents as per synthesis route of synthesis of Iguratimod. Range for these method is listed for each solvent - Ethanol (50ppm - 7500ppm), Acetone (50ppm - 7500ppm), Isopropyl alcohol (50ppm - 7500ppm), Acetonitrile (20ppm - 615ppm), Dichloromethane (30ppm - 900ppm), Ethyl acetate (50ppm - 7500ppm), Methanol (30ppm - 4500ppm), Pyridine (20ppm - 300ppm), Dimethyl formamide (88ppm - 1320ppm), Benzene (0.2ppm - 3ppm), Nitrobenzene (3ppm - 45ppm). All five methods are having the coefficient of variation (r) not less than 0.99. This proposed methodology was found precise, linear and accurate for the specified range for respective solvents. Keywords: Iguratimod, validation, development. Download PDF


Title: PRANAYAMA HEALTH SCALE: CONCEPTUALIZATION, DEVELOPMENT, VALIDATION AND RELIABILITY FOR ADOLESCENTS’ WELL BEING
Author: Sadhna Dadhore, G. Paran Gowda
Keyword: Pranayama; Health; Psychometric properties; Instrumental study.
Page No: 265-275
DOI: 10.30876/JOHR.6.4.2018.265-275
Abstract: Pranayama techniques are enshrined in the ancient Indian yoga text books. The concept on pranayama health scale (PHS) is developed based on these scriptures. The present study is an attempt to develop a psychometric scale entitled Pranayama Health Scale (PHS) to measure individuals’ physical and mental health and pranic wellbeing. A sample size of 1,253 adolescents was recruited on a convenient sampling basis to evaluate the psychometric properties of PHS. Content validity and face validity were done as a part of theoretical analysis. Construct validity was assessed through Exploratory Factor Analysis and Confirmatory Factor Analysis using SPSS and AMOS version 25. Reliability of the scale was tested using Cronbach’s alpha and Spearman-Brown coefficient. The final scale consisted of 12 items, which produced a latent variable with Spearman-Brown coefficient of 0.97 and Cronbach’s alpha of 0.96. PHS scores are positively correlated (p<0.001) with Yoga Self-Efficacy Scale (YSES). Goodness of Fit indices comprising Absolute, Incremental and Parsimonious fits were also calculates from the scale scores are within the accepted range confirming the validity of the model. The pranayama scale could be beneficial for the general health and well being of adolescent groups. Key words: Pranayama; Health; Psychometric properties; Instrumental study. Download PDF


Title: PREDICTIVE ANALYSIS OF OPIOD AND NON-OPIOD PRESCRIBER FOR IMPROVING ACCURACY USING IMPROVE XGBOOSTING SYSTEM
Author: Ms. Anjali, Mr. Shivendra Dubey, Mr. Rakesh Shivhare, Mr. Mukesh Dixit
Keyword: XG Boosting, Machine Learning, Accuracy, Tree Model, Predictive Modeling
Page No: 276-285
DOI: 10.30876/JOHR.6.4.2018.276-285
Abstract: Tree boosting has exactly ended up being a profoundly e?ective way to deal with predictive modeling. It has indicated significant outcomes for an immense range of issues. We will demonstrate that XGBo ost utilizes a boosting calculation which we will use Newton boosting. This boosting calculation will additionally be contrasted and the gradient boosting calculation that MART utilizes. In addition, we will examine the regularization procedures that these strategies over along with these have on the models. We examine the XGBoost and Improved XGBoost claasifiers for both Opiod as well as Non – Opiod prescribers in terms of Accuracy and AUC score. Keywords: XG Boosting, Machine Learning, Accuracy, Tree Model, Predictive Modeling Download PDF


Title: FORMULATION AND IN VITRO EVALUATION OF IMMEDIATE RELEASE SOFTGEL OF NAPROXEN SODIUM
Author: Deepak Sarangi*, Suman Kumar Mekap, Sujit Kumar Patro, Rabinarayan Rana, Monalisa Mahapatra
Keyword: Soft gel, Naproxen Sodium, bioavailability
Page No: 286-296
DOI: 10.30876/JOHR.6.4.2018.286-296
Abstract: Oral drug delivery has been known for decades as the most widely utilized route of administered among all the routes that have been employed for the systemic delivery of drug via various pharmaceutica l products of different dosage forms. The reasons that the oral route achieved such popularity may be in part attributed to its ease of administration and the belief that oral administration of the drug is well absorbed. One such area of research is design of Softgel technology. Softgel technology is one of the most attractive and promising approach for increasing oral bioavailability by means of increasing solubility of the poorly soluble drug. Naproxen Sodium is one of the most important Non-steroidal anti-inflammatory agents used in the treatment of acute to chronic pains, inflammation and it belongs to BCS class-II drug so as to increase its aqueous solubility for enhancing the bioavailability, it is formulated as a liquid filled soft gelatin capsules. Key Words: Soft gel, Naproxen Sodium, bioavailability Download PDF


Title: TOPICAL ANALGESIC ACTIVITY OF CLOVE GEL
Author: Padhan K Dipti, Samantaray Kiran, Mohanty Arnabaditya, Padhan Jyotirmayee
Keyword: Clove gel, in vivo, hot plate method, tail immersion
Page No: 84-88
DOI: 10.30876/JOHR.7.4.2018.84-88
Abstract: Objective: To study the topical analgesic activity of gel containing clove. Methods: The essential oil was extracted from flower bud of Eugenia cryphyllus. Topical gel containing essential oil was inv estigated for analgesic activity in albino rat using hot-plate method. Diclofenac sodium gel was taken as standard drug. Results: The analgesic activity of topical gel preparation was observed in the early phase. The analgesic activity of topical preparation containing 5% Eugenia cryphyllus essential oil showed same analgesic activity compare to standard drug diclofenac sodium (7.833±0.31) at 120 minutes, whereas the test drug showed significant activity (8.166±0.65) than the standard drug (6.5±0.34) at 180 minutes of application of drug by hot-plate method (p<0.001). Conclusion: Hence it may suggest that the essential oil of Eugenia cryphyllus attribute potent analgesic activity. Keywords: Clove gel, in vivo, hot plate method, tail immersion Download PDF


Title: DESIGN AND DEVELOPMENT OF SELF EMULSIFYING DRUG DELIVERY SYSTEM OF ZIPRASIDONE HYDROCHLORIDE
Author: Lodhi Devendra Singh and Dr. Kuldeep Ganju
Keyword: Self-emulsifying drug delivery, oleic acid, tween 80, PEG 400, Ziprasidone Hydrochloride
Page No: 89-97
DOI: https://doi.org/10.30876/johr.7.4.2018.89-97
Abstract: Ziprasidone is used in a treatment of schizophrenia, belongs to BCS class IIdrug (low solubility and high permeability). It undergoes extensive first pass metabolism with a bioavailability of only abo ut 60%.The major drawback in the therapeutic application and efficacy of ziprasidone as oral dosage form is its low aqueous solubility. Hence this work was planned to improve dissolution characteristics of the drug by increasing its release and solubility through self emulsifying drug delivery system. In the study, self-emulsifying drug delivery system (SEDDS) of ziprasidone hydrochloride, a poorly soluble drug, was developed and evaluated by in-vitro techniques. Oil, surfactant, and cosurfactant were screened out according to their solubilizing capacity. Among the tested components Oleic acid, Tween-80, PEG 400 showed good solubilizing capacity. These three components were used in different ratios to prepare Ziprasidone SEDDS. The SEDDS formulations were transparent and clear. Droplet size of the emulsion was determined by Malvern Zeta sizer. Formulation F8 minimum mean droplet size (244.7nm). In-vitro drug release from F8 was higher (98% within 120 min) than other formulations. So SEDDS may be an alternative technique for the oral administration of Ziprasidone Hydrochloride. Keyword: Self-emulsifying drug delivery, oleic acid, tween 80, PEG 400, Ziprasidone Hydrochloride Download PDF


Title: 3D PRINTING: A REVIEW
Author: Shubham Bairagi, Mr.Kuldeep Vinchurkar* Rahul Kushwah, Dr.Neelam Balekar
Keyword: Bioprinter, biomimicry, biocells, tissues, organs, bioprinting techniques
Page No: 98-104
DOI: 10.30876/JOHR.7.4.2018.98-104
Abstract: This review article is a summary of organ and tissue showing 3D printing. Processing 3D of appropriate shape, structure and size is the most difficult and challenging job for tissue engineering Tissu e organ printer is being presented by us which is exclusively designed for constructing similar shapes and sizes, which is possible by using biodegradable polymers while printing cell-laden hydrogels. The right shape of the tissue can be attained and it is possible by representing clinical imaging data as computer model of the anatomical defect and also to interpret the model into various programs that are used to control the movement of the printer nozzles. The incorporation of micro channels into the tissue constructs facilitated diffusion of nutrients to printed cells, and as a result it overcomes the diffusion limit of 100-200 µm for cell survival in engineered tissues. We demonstrated the ability of ITOP by making mandible and calvarial bones, cartilages and skeletal muscles. The ITOP can be used in future in developing or making of more complex tissues and organs of solid nature. Keywords: Bioprinter, biomimicry, biocells, tissues, organs, bioprinting techniques Download PDF


Title: INVESTIGATING COMPLEX FINANCIAL CRIME – A CASE STUDY INSPIRED BY THE POLLY PECK PLC FRAUD
Author: Paul Eisenberg
Keyword: : Financial fraud investigation, Data Mining, Benford’s law, Neural Networks, Specific Item Method
Page No: 124-135
DOI: 10.30876/JOHR.4.4.2018.124-135
Abstract: The purpose of this article is to illustrate a financialfraud investigation by the way of a case study inspired by the famous Polly Peck PLC fraud case. After exploring the features of an investigatio n plan, false accounting and theft charges are explained and exemplified. Various techniques of tracing the crime proceeds are analysed, as well as investigative models and methods to provide evidence. Methodologically, economic fraud investigations are discussed through an in-depth literature review. The investigative models applied are characterised by Data Mining techniques (Decision Trees, Neural Networks and Benford’s law) as well as the Net Worth Method, the Bank Deposit Method, the Specific Item Method and Digital Link Analysis. The case study shows that Benford’s law and Neural Networks, together with the Specific Item Method can render results admissible in criminal court in cumbersome financial fraud cases involving several jurisdictions and complex banking arrangements. Keywords: Financial fraud investigation, Data Mining, Benford’s law, Neural Networks, Specific Item Method Download PDF