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Title: ONE-FACTOR-AT-A-TIME (OFAT) OPTIMIZATION OF ?-GALACTOSIDASE PRODUCTION FROM ASPERGILLUS FLAVUS GR. NFCCI-2728 IN SUBMERGED FERMENTATION.
Author: J. D. Patel*, B. V. Raol, N. H. Bhavsar and G. G. Raol*
Keyword: Aspergillus flavus, OFAT, Submerged fermentation, Czapek’s-Lactose broth.
Page No: 227-235
DOI: 10.30876/JOHR.6.4.2018.227-235
Abstract: Production of ß-galactosidase enzyme under submerged fermentation was carried out using Aspergillus flavus gr. NFCCI-2728. Optimization of different cultural conditions viz., incubation time, nitrogen source and its concentration, carbon source and its concentration, pH and inoculum size were carried out using one factor at time approach (OFAT) in Czapek’s-Lactose (CL) Medium for enhanced production of ß-galactosidase enzyme. The highest yield of ß-galactosidase was achieved 843.75 Umg-1 which was 4.75 times higher than unoptimized medium. Keywords: Aspergillus flavus, OFAT, Submerged fermentation, Czapek’s-Lactose broth. Download PDF


Title: APPLICATIONS OF LINEAR ALGEBRA IN GENETICS
Author: M. Naga Maruthi Kumari, Kavya.H.U and Krupashree .Y.N
Keyword: Eigen values, Eigen vectors, Diagonalization, Autosomal inheritance, Genotype, genotype distribution.
Page No: 236-240
DOI: 10.30876/JOHR.6.4.2018.236-240
Abstract: The present paper is focusing on the Mathematical concepts from Linear Algebra including Eigen values and eigen vectors and disgonalization to predict the genotype distribution. This paper is based on finding the genotype distribution for nth generation in Autosomal inheritance. Key Words: Eigen values, Eigen vectors, Diagonalization, Autosomal inheritance, Genotype, genotype distribution. Download PDF


Title: A MEASURE OF YOGA PERSONAL OBSERVANCE (NIYAMA): A CONFIRMATORY FACTOR ANALYSIS
Author: Sadhna Dadhore, G. Paran Gowda
Keyword: Yoga, Personal observance or niyama, Personality, Scale development.
Page No: 241-253
DOI: 10.30876/JOHR.6.4.2018.241-253
Abstract: The background idea on yoga personal observance is given in the form of an aphorism in astanga yoga (eight limbed yoga). The concept on yoga personal observance scale (YPOS) is developed based on yoga books. The purpose of this paper is to develop a yoga personal observance scale using confirmatory factor analysis. A psychometric analysis of cronbach alpha, validity, reliability, correlation factor loadings, factor extraction from a uni-diagonal matrix, reduced items, fitness indices etc. We used SPSS and AMOS version 25 exploratory and confirmatory factor analyses to develop YPOS. To test the scale, we randomly selected 1,304 participants from general populations of Bhopal city, India. The developed 28-item five factor YPOS comprised standardized regression coefficients with 58.46% variance with a Cronbach’s alpha of 0.76. The results of three different model Fitness categories of indexes with construct, convergent, concurrent validity were also analyzed and found to be acceptable. There is a scope for further research development in each of the eight limbed yoga practices. Keywords: Yoga, Personal observance or niyama, Personality, Scale development. Download PDF


Title: ANALYTICAL METHOD DEVELOPMENT AND VALIDATION BY HEADSPAVE GAS CHROMATOGRAPHY FOR RESIDUAL SOLVENTS IN IGURATIMOD
Author: Ravindra B. Nehete, Pushpendra Sharma
Keyword: Iguratimod, validation, development.
Page No: 254-264
DOI: 10.30876/JOHR.6.4.2018.254-264
Abstract: Testing of residual solvent is a primary requirement for any drug substance. These studies provide information about the residual solvents content in Iguratimod with simple, accurate, precise by heads pace gas chromatography. Method by head space gas chromatography with flame ionization detector has been developed and validated to detect and quantitate the specified solvents. Baseline separation in-between the peaks were been achieved by suing capillary column with a flame ionization detector. Percentage recovery obtained in the range of 80-120% and the method is linear for all the specified solvents as per synthesis route of synthesis of Iguratimod. Range for these method is listed for each solvent - Ethanol (50ppm - 7500ppm), Acetone (50ppm - 7500ppm), Isopropyl alcohol (50ppm - 7500ppm), Acetonitrile (20ppm - 615ppm), Dichloromethane (30ppm - 900ppm), Ethyl acetate (50ppm - 7500ppm), Methanol (30ppm - 4500ppm), Pyridine (20ppm - 300ppm), Dimethyl formamide (88ppm - 1320ppm), Benzene (0.2ppm - 3ppm), Nitrobenzene (3ppm - 45ppm). All five methods are having the coefficient of variation (r) not less than 0.99. This proposed methodology was found precise, linear and accurate for the specified range for respective solvents. Keywords: Iguratimod, validation, development. Download PDF


Title: PRANAYAMA HEALTH SCALE: CONCEPTUALIZATION, DEVELOPMENT, VALIDATION AND RELIABILITY FOR ADOLESCENTS’ WELL BEING
Author: Sadhna Dadhore, G. Paran Gowda
Keyword: Pranayama; Health; Psychometric properties; Instrumental study.
Page No: 265-275
DOI: 10.30876/JOHR.6.4.2018.265-275
Abstract: Pranayama techniques are enshrined in the ancient Indian yoga text books. The concept on pranayama health scale (PHS) is developed based on these scriptures. The present study is an attempt to develop a psychometric scale entitled Pranayama Health Scale (PHS) to measure individuals’ physical and mental health and pranic wellbeing. A sample size of 1,253 adolescents was recruited on a convenient sampling basis to evaluate the psychometric properties of PHS. Content validity and face validity were done as a part of theoretical analysis. Construct validity was assessed through Exploratory Factor Analysis and Confirmatory Factor Analysis using SPSS and AMOS version 25. Reliability of the scale was tested using Cronbach’s alpha and Spearman-Brown coefficient. The final scale consisted of 12 items, which produced a latent variable with Spearman-Brown coefficient of 0.97 and Cronbach’s alpha of 0.96. PHS scores are positively correlated (p<0.001) with Yoga Self-Efficacy Scale (YSES). Goodness of Fit indices comprising Absolute, Incremental and Parsimonious fits were also calculates from the scale scores are within the accepted range confirming the validity of the model. The pranayama scale could be beneficial for the general health and well being of adolescent groups. Key words: Pranayama; Health; Psychometric properties; Instrumental study. Download PDF


Title: PREDICTIVE ANALYSIS OF OPIOD AND NON-OPIOD PRESCRIBER FOR IMPROVING ACCURACY USING IMPROVE XGBOOSTING SYSTEM
Author: Ms. Anjali, Mr. Shivendra Dubey, Mr. Rakesh Shivhare, Mr. Mukesh Dixit
Keyword: XG Boosting, Machine Learning, Accuracy, Tree Model, Predictive Modeling
Page No: 276-285
DOI: 10.30876/JOHR.6.4.2018.276-285
Abstract: Tree boosting has exactly ended up being a profoundly e?ective way to deal with predictive modeling. It has indicated significant outcomes for an immense range of issues. We will demonstrate that XGBo ost utilizes a boosting calculation which we will use Newton boosting. This boosting calculation will additionally be contrasted and the gradient boosting calculation that MART utilizes. In addition, we will examine the regularization procedures that these strategies over along with these have on the models. We examine the XGBoost and Improved XGBoost claasifiers for both Opiod as well as Non – Opiod prescribers in terms of Accuracy and AUC score. Keywords: XG Boosting, Machine Learning, Accuracy, Tree Model, Predictive Modeling Download PDF


Title: FORMULATION AND IN VITRO EVALUATION OF IMMEDIATE RELEASE SOFTGEL OF NAPROXEN SODIUM
Author: Deepak Sarangi*, Suman Kumar Mekap, Sujit Kumar Patro, Rabinarayan Rana, Monalisa Mahapatra
Keyword: Soft gel, Naproxen Sodium, bioavailability
Page No: 286-296
DOI: 10.30876/JOHR.6.4.2018.286-296
Abstract: Oral drug delivery has been known for decades as the most widely utilized route of administered among all the routes that have been employed for the systemic delivery of drug via various pharmaceutica l products of different dosage forms. The reasons that the oral route achieved such popularity may be in part attributed to its ease of administration and the belief that oral administration of the drug is well absorbed. One such area of research is design of Softgel technology. Softgel technology is one of the most attractive and promising approach for increasing oral bioavailability by means of increasing solubility of the poorly soluble drug. Naproxen Sodium is one of the most important Non-steroidal anti-inflammatory agents used in the treatment of acute to chronic pains, inflammation and it belongs to BCS class-II drug so as to increase its aqueous solubility for enhancing the bioavailability, it is formulated as a liquid filled soft gelatin capsules. Key Words: Soft gel, Naproxen Sodium, bioavailability Download PDF