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Title: TOPICAL ANALGESIC ACTIVITY OF CLOVE GEL
Author: Padhan K Dipti, Samantaray Kiran, Mohanty Arnabaditya, Padhan Jyotirmayee
Keyword: Clove gel, in vivo, hot plate method, tail immersion
Page No: 84-88
DOI: 10.30876/JOHR.7.4.2018.84-88

Abstract: Objective: To study the topical analgesic activity of gel containing clove. Methods: The essential oil was extracted from flower bud of Eugenia cryphyllus. Topical gel containing essential oil was inv estigated for analgesic activity in albino rat using hot-plate method. Diclofenac sodium gel was taken as standard drug. Results: The analgesic activity of topical gel preparation was observed in the early phase. The analgesic activity of topical preparation containing 5% Eugenia cryphyllus essential oil showed same analgesic activity compare to standard drug diclofenac sodium (7.833±0.31) at 120 minutes, whereas the test drug showed significant activity (8.166±0.65) than the standard drug (6.5±0.34) at 180 minutes of application of drug by hot-plate method (p<0.001). Conclusion: Hence it may suggest that the essential oil of Eugenia cryphyllus attribute potent analgesic activity. Keywords: Clove gel, in vivo, hot plate method, tail immersion Download PDF

Title: DESIGN AND DEVELOPMENT OF SELF EMULSIFYING DRUG DELIVERY SYSTEM OF ZIPRASIDONE HYDROCHLORIDE
Author: Lodhi Devendra Singh and Dr. Kuldeep Ganju
Keyword: Self-emulsifying drug delivery, oleic acid, tween 80, PEG 400, Ziprasidone Hydrochloride
Page No: 89-97
DOI: https://doi.org/10.30876/johr.7.4.2018.89-97

Abstract: Ziprasidone is used in a treatment of schizophrenia, belongs to BCS class IIdrug (low solubility and high permeability). It undergoes extensive first pass metabolism with a bioavailability of only abo ut 60%.The major drawback in the therapeutic application and efficacy of ziprasidone as oral dosage form is its low aqueous solubility. Hence this work was planned to improve dissolution characteristics of the drug by increasing its release and solubility through self emulsifying drug delivery system. In the study, self-emulsifying drug delivery system (SEDDS) of ziprasidone hydrochloride, a poorly soluble drug, was developed and evaluated by in-vitro techniques. Oil, surfactant, and cosurfactant were screened out according to their solubilizing capacity. Among the tested components Oleic acid, Tween-80, PEG 400 showed good solubilizing capacity. These three components were used in different ratios to prepare Ziprasidone SEDDS. The SEDDS formulations were transparent and clear. Droplet size of the emulsion was determined by Malvern Zeta sizer. Formulation F8 minimum mean droplet size (244.7nm). In-vitro drug release from F8 was higher (98% within 120 min) than other formulations. So SEDDS may be an alternative technique for the oral administration of Ziprasidone Hydrochloride. Keyword: Self-emulsifying drug delivery, oleic acid, tween 80, PEG 400, Ziprasidone Hydrochloride Download PDF