Current Issue ( Vol. : 9, Issue: 2, April-June 2020)   


Title: DEVELOPMENT AND VALIDATION OF A SIMPLE UV SPECTROPHOTOMETRIC AND STRESS STUDIES METHOD FOR THE DETERMINATION OF VALACYCLOVIR HYDROCHLORIDE BOTH IN BULK AND MARKETED DOSAGE FORMULATIONS
Author: Dr.K. Bhavyasri*, M.V.S. Lavanya and Dr. Mogili. Sumakanth
Keyword: Valacyclovir hydrochloride, UV spectrophotometric method, validation, method development.
Page No: 20-26
DOI: 10.30876/JOHR.9.2.2020.20-26
Abstract: A simple, accurate, precise UV spectrophotometric method was developed in pure and pharmaceutical formulations for Valacyclovir hydrochloride. It is a antiviral drug. Valacyclovir hydrochloride exhibi ting maximum absorbance at 251 nm in distilled water and the method was validated for linearity, precision, sensitivity, and specificity. The drug obeyed linearity at concentration range of 2-32 µg/ml. The proposed method was validated statistically with significant high value of correlation coefficient 0.999. The percentage recovery value for Valacyclovir hydrochloride was in the range of 99.1 –99.7%. Therefore, the proposed method could be applied for the routine analysis of pharmaceutical dosage forms containing Valacyclovir hydrochloride. Forced degradation studies were also performed.Download PDF


Title: STUDY OF POWDER AND TABLETING FUNCTIONALITY TOWARDS EVALUATION AND CHARACTERISATION OF BARETab® PH (ALL IN ONE EXCIPIENT) AS A SUBSTITUTE OF CONVENTIONAL PHYSICALLY MIXED MICROCRYSTALLINE CELLULOSE, CROSCARMELLOSE SODIUM, SILICON DIOXIDE AND PURIFIED TALC IN A PCM FORMULATION
Author: Monika Tomar, *Amit Raj Sinha
Keyword: Co-Processed Excipient BARETab® PH, True density, Compressibility, SEM, Surface area, Paracetamol DC tablet.
Page No: 27-36
DOI: 10.30876/JOHR.9.2.2020.27-36
Abstract: BARETab® PH is a multi-functional ready to use premixed, co-processed ingredient for direct compression (DC) formulations. It is a combination of selective, largely used excipients for DC. Direct comp ression is the most widely used tableting method because of the simple manufacturing process with higher output in a shorter time. In DC formulations, the major disadvantage is due to heterogeneous mixture of excipients and API. Mostly APIs have poor flowability and compressibility, which cause weight, hardness variation, high friability and unequal API distribution in the tablets. In general, excipients and APIs have different particle size which makes heterogeneous mixture challenging. Fine particles of API and excipient cause physical defects like sticking, capping and lamination in formulations. BARETab® PH can solve all these problems primarily due to its homogeneous mixing, larger surface area and superior flowability which carries the API and allows equal distribution in the tablets. BARETab® PH facilitates better uniformity, higher tablet hardness, shorter disintegration time and eliminates physical tableting defects. In this study, we have produced Paracetamol (PCM) tablet by direct compression with improved tablet properties and shortened manufacturing time when compared to the wet granulation methodDownload PDF