ARCHIVES(Journal of Harmonized Research in Pharmacy)

Author: Padhan K Dipti, Samantaray Kiran, Mohanty Arnabaditya, Padhan Jyotirmayee
Keyword: Clove gel, in vivo, hot plate method, tail immersion
Page No: 84-88
DOI: 10.30876/JOHR.7.4.2018.84-88
Abstract: Objective: To study the topical analgesic activity of gel containing clove. Methods: The essential oil was extracted from flower bud of Eugenia cryphyllus. Topical gel containing essential oil was inv estigated for analgesic activity in albino rat using hot-plate method. Diclofenac sodium gel was taken as standard drug. Results: The analgesic activity of topical gel preparation was observed in the early phase. The analgesic activity of topical preparation containing 5% Eugenia cryphyllus essential oil showed same analgesic activity compare to standard drug diclofenac sodium (7.833±0.31) at 120 minutes, whereas the test drug showed significant activity (8.166±0.65) than the standard drug (6.5±0.34) at 180 minutes of application of drug by hot-plate method (p<0.001). Conclusion: Hence it may suggest that the essential oil of Eugenia cryphyllus attribute potent analgesic activity. Keywords: Clove gel, in vivo, hot plate method, tail immersion Download PDF

Author: Lodhi Devendra Singh and Dr. Kuldeep Ganju
Keyword: Self-emulsifying drug delivery, oleic acid, tween 80, PEG 400, Ziprasidone Hydrochloride
Page No: 89-97
Abstract: Ziprasidone is used in a treatment of schizophrenia, belongs to BCS class IIdrug (low solubility and high permeability). It undergoes extensive first pass metabolism with a bioavailability of only abo ut 60%.The major drawback in the therapeutic application and efficacy of ziprasidone as oral dosage form is its low aqueous solubility. Hence this work was planned to improve dissolution characteristics of the drug by increasing its release and solubility through self emulsifying drug delivery system. In the study, self-emulsifying drug delivery system (SEDDS) of ziprasidone hydrochloride, a poorly soluble drug, was developed and evaluated by in-vitro techniques. Oil, surfactant, and cosurfactant were screened out according to their solubilizing capacity. Among the tested components Oleic acid, Tween-80, PEG 400 showed good solubilizing capacity. These three components were used in different ratios to prepare Ziprasidone SEDDS. The SEDDS formulations were transparent and clear. Droplet size of the emulsion was determined by Malvern Zeta sizer. Formulation F8 minimum mean droplet size (244.7nm). In-vitro drug release from F8 was higher (98% within 120 min) than other formulations. So SEDDS may be an alternative technique for the oral administration of Ziprasidone Hydrochloride. Keyword: Self-emulsifying drug delivery, oleic acid, tween 80, PEG 400, Ziprasidone Hydrochloride Download PDF

Author: Shubham Bairagi, Mr.Kuldeep Vinchurkar* Rahul Kushwah, Dr.Neelam Balekar
Keyword: Bioprinter, biomimicry, biocells, tissues, organs, bioprinting techniques
Page No: 98-104
DOI: 10.30876/JOHR.7.4.2018.98-104
Abstract: This review article is a summary of organ and tissue showing 3D printing. Processing 3D of appropriate shape, structure and size is the most difficult and challenging job for tissue engineering Tissu e organ printer is being presented by us which is exclusively designed for constructing similar shapes and sizes, which is possible by using biodegradable polymers while printing cell-laden hydrogels. The right shape of the tissue can be attained and it is possible by representing clinical imaging data as computer model of the anatomical defect and also to interpret the model into various programs that are used to control the movement of the printer nozzles. The incorporation of micro channels into the tissue constructs facilitated diffusion of nutrients to printed cells, and as a result it overcomes the diffusion limit of 100-200 µm for cell survival in engineered tissues. We demonstrated the ability of ITOP by making mandible and calvarial bones, cartilages and skeletal muscles. The ITOP can be used in future in developing or making of more complex tissues and organs of solid nature. Keywords: Bioprinter, biomimicry, biocells, tissues, organs, bioprinting techniques Download PDF