ARCHIVES(Journal of Harmonized Research in Pharmacy)


Title: FORMULATION DEVELOPMENT AND EVALUATION OF LOZENGES CONTAINING POLYHERBAL EXTRACT OF CINNAMOMUM TAMALA AND SPILANTHES ACMELLA
Author: Pooja C. Deshpande, Dinesh M. Biyani, Avinash O, Maske, Dr.Milind Umekar and Bhushan Hatwar
Keyword: Cinnamomum Tamala and Spilanthes Acmella extract, antimicrobial evaluation, Phytochemical screening, lozenges, evaluation parameter.
Page No: 01-10
DOI: 10.30876/JOHR.9.1.2020.01-10
Abstract: In recent year, the growing demand of herbal has lead to a quantum jump in a volume of plant material traded within and across the country. Cinnamomum Tamala and Spilanthes Acmella is an important me dicinal plant, commonly known as Tejpatta (Cinnamomum Tamala ) and Akarkara (Spilanthes Acmella) which rich source of therapeutic constituent. The aim of this research to develop of modern dosage form such as lozenges associated with an extended period of local remedy with beneficial therapeutic effect. The combination of Cinnamomum Tamala leaves and Spilanthes Acmella flowers extract exhibit antimicrobial property against the selected microorganism (staphylococcus aureus, streptococcus mutans and Escherichia coli). The qualitative Phytochemical screening of ethanol, methanol and petroleum ether extracts of both Cinnamomum Tamala leaves and Spilanthes Acmella flowers extract was performed and confirmed the presence of many phytochemicals like alkaloids, flavonoids, glycosides and triterpenes . From the result obtained it can be concluded that the optimized formula F3 was selected for the formulation of tablet lozenges and was prepared by direct compression method which exhibit optimum friability, weight uniformity, hardness and disintegration time. Download PDF


Title: FORMULATION & EVALUATION OF BUDESONIDE CONTROLLED RELEASE CAPSULES BY SUSPENSION LAYERING METHOD
Author: Verma Mithun and Gupta Vishvnath
Keyword: Multiunit Pellet Systems, Suspension Layering Method, Budesonide, Controlled Release.
Page No: 11-16
Abstract: The study was undertaken with an aim to formulate budesonide controlled release capsules. The drug budesonide is corticosteroid and used for the treatment of Crohn’s disease. Before going to develop t he formulation, a detail product literature review was carried out to know about the innovator’s product and the patent status of the drug. Preformulation study involving drug -excipients compatibility was done initially and results indicated the compatibility with all the tested excipients. The study was carried out by solution/suspension matrix layering method. In this method first drug and polymer solutions were mixed, coating was done on the sugar spheres; further enteric coating was done on polymer matrix coated pellets. Different trials were conducted with various percentages of polymer in first stage and second stage (during enteric coating), and the formulation was finally optimized based on the drug release profile. Pellets were evaluated by in vitro dissolution. These studies revealed that the F6 pellets were found to be release the drug almost comparable to that of innovator’s product. Further, the F6 formulation was subjected to release studies at different pH conditions and found to have similar release profile as that of innovator. The in vitro dissolution tests were performed and f2 values were calculated for all trials. Dissolution profile of formulation F6 matched with that of the innovator’s product and f2 value was satisfactory. Stability studies were also performed; both accelerated and long term stability studies were conducted for two months. During this study, the formulation F6 was found to be stable and no differences in the assay and release characteristics were noticed. Download PDF


Title: DEVELOPMENT AND VALIDATION OF SPECTROPHOTOMETRIC METHOD FOR ESTIMATION OF ALBENDAZOLE DISSOLUTION STUDY
Author: Khushboo Gupta, Sudeep Mandal, Pranjul Shrivastava, Poonam Sahu
Keyword: Albendazole, UV-Vis Spectrophotometer, Recovery, Validation
Page No: 17-19
DOI: 10.30876/JOHR.9.1.2020.17-19
Abstract: Abstract:In the biopharmaceutical classification system, albendazole is a class II drug, so its dissolution analysis is very difficult due to its low solubility and difficulty in estimating product in bulk. The present study deals with the design and validation of UV spectrophotometric methods to estimate albendazole in bulk form.Albendazole is a benzimidazole derivative that has an oral wide range of activity against parasites of human and animal helminths.The drug was obeying the law of the Beer and showing good correlation.It showed a peak absorption of sodium lauryl sulphate (SLS) at 229 nm in 0.1 N HCl.Linearity of 420µg / ml was observed.The method was used in the pure, tablet and suspension forms to analyze the drug. The regression line equation slope and intercept is 0.009 and 0.017 respectively. It was found that the coefficient of correlation was 0.9996.Restoration trials have confirmed the findings of the study. The restoration has reached 97%. The method has been found to be simple, effective, fast, precise, detailed and reproducible and can be used in different dosage type and dissolution studies for routine analysis of albendazole. Download PDF