Journal of Harmonized Research in Pharmacy

ANTICANCER ACTIVITY OF ETHANOL EXTRACT OF SONERILA TINNEVELLIENSIS FISCHER WHOLE PLANT AGAINST DALTON ASCITES LYMPHOMA

Abstract

Author(s): Komalavalli. T, Packia Lincy. M, Muthukumarasamy. S and Mohan V.R

The ethanol extract of whole plant of S. tinnevelliensis was evaluated for antitumor activity against Dalton’s ascites lymphoma (DAL)-bearing swiss albino mice. The extract was administered at the dos es of 200 and 400 mg/kg body weight per day for 14 days after 24h of tumor inoculation. Evaluation of the antitumor effect of ethanol extract of whole plant of S. tinnevelliensis on tumor growth and host survival time was made by the study of the following parameters: tumor volume, viable and non viable cell count and life span of host. The results showed decrease in tumor volume and viable cell count. Haematological studies revealed that, the Hb count decreased in DAL treated mice, whereas it was induced by the drug treated animals and showed an increase in Hb near to normal levels. The results suggested that the extract of whole plant of S. tinnevelliensis exhibited significant antitumor activity on DAL bearing mice. Keywords: S. tinnevelliensis, Antitumor, DAL, tumor volume, HB, haematological profile.