Journal of Harmonized Research in Pharmacy

ANTICONVULSANT PROFILE OF COMBINATION OF ANNONA SQUAMOSA, NARDOSTACHYS JATAMANSI AND BACOPA MONNIERI AND EPI CAPS IN MICE

Abstract

Author(s): Foram Parikh, Kedar Prabhavalkar

Several studies have indicated the role of Annona squamosa, Nardostachys jatamansi, Bacopa monnieri for its anti convulsant effects individually. Thus a combination of these extracts along with a mar keted formulation Epi caps was evaluated for its anti convulsant potency. Acute Oral Toxicity was performed as per OECD 423 and this combination was found to be safe upto 2000mg/kg. The combination of extracts was given in 100mg/kg and 200mg/kg for 14 days. The anti convulsant potency of these drugs was evaluated using Pentylenetetrazole and Maximal electroshock models for epilepsy in mice. The results evidently suggest that the combination of extracts as well as Epi caps were able to control the extent and severity of seizures in PTZ and MES models.