Journal of Harmonized Research in Pharmacy

ANTI-PARKINSONISM ACTIVITY OF SARACA ASOCA BY HALOPERIDOL INDUCED MODEL

Abstract

Author(s): C. Velmurugan, K.Sapura, G. Indira Priyadarshini, S. Vijaya Kumar, B. Sasivardhan Reddy & M. Akmal Ali Baig

Aim: The present study was designed to investigate the effects of different extracts of leaves of Saraca asoca in haloperidol induced Parkinsonism experimental model. Methods: Swiss albino mice of ei ther sex, weighing about 20-25 gm were used. Anti parkinsonism activity was done by haloperidol induced model using catalepsy score by Hole board test and catatonic score by block model and also evaluated in-vivo antioxidant, estimation of dopamine, nor adrenaline, adrenaline from brain tissue and histopathalogical studies of brain. Results: The extracts of AESA, MESA & WESA at doses (200 mg/Kg, p.o.) revealed the anti-parkinsonism activity while the PESA non significant to Parkinsonism control. The anti-parkinsonism activity was confirmed by Catatonic score, Head dip, number of line crossing, anti-oxidant enzyme level, LPO, histology of brain and level of monoamines like dopamine etc. at the dose levels of (200 mg/Kg, p.o.). The extracts MESA & WESA significantly decreased the Catatonic score and increased the head dip & number of line crossing. The dopamine, nor adrenaline and adrenaline significantly increased with extracts treated group except PESA at a dose of 200 mg/kg. Extracts MESA & WESA (200 mg/Kg, p.o.) has shown significant morphological changes when compared to haloperidol administered group. Conclusion: The results of the present work suggested that the MESA & WESA has a potent antiparkinsonism activity.