Journal of Harmonized Research in Pharmacy

APPROCHES TO REDUCE TOXICITY OF ANTICANCER DRUG

Abstract

Author(s): Shweta Dutta*, Debashish Paramanick, Kamal Babu Aditya, Vijay Kumar Singh and Deepak Kumar Dash

Around the world, remarkable resource is being investigated for in prevention, diagnostic and treatment of cancer. Cancer is second leading cause of death. The current approach to treat cancer by main ly chemotherapy agent, radiation and surgery, but main obstacle is to lack of selectivity result in toxicity to non cancerous proliferative cell .conventional anticancer drug exhibit much toxic effect in the body. So in this review focus approaches to treat cancer with minimum adverse effect. The possible approaches regarding, site specific drug targeting by polymeric drug, ligand conjugated drug which directly binding to cancer cell by cancer targeting receptor. Also discuss about chemoprotective agent, dose reduction intermittent therapy and drug polymer which help to help reduce toxicity. Unique challenge and opportunity in these work help to anticancer drug development.