Journal of Harmonized Research in Pharmacy

DESIGNING AND PERFORMANCE EVALUATION OF CLARITHROMYCIN BIOADHESIVE TABLET

Abstract

Author(s): Atul Gunjal*, Santosh Ghule, Gali Vidyasagar

The objective of present research work was to design and evaluate bioadhesive tablets of clarithromycin. Tablets were prepared by wet granulation technique and evaluated for pre-compression as well a s post compression parameters. Different formulation batches (C1-C6) were prepared and evaluated for characteristics parameters like hardness, friability, drug content, weight variation etc. Tablets were also evaluated for bioadhesive strength, and in vitro release profile. Further data obtained from in vitro release study was subjected to release kinetics. Results suggested that batch C1 showed controlled release with excellent bioadhesive strength. Key words: Bioadhesive, Controlled release, Granulation, Compression, Release kinetics.