Journal of Harmonized Research in Pharmacy

EVALUATION OF ANTICONVULSANT ACTIVITY OF LEAF EXTRACTS OF SECURINEGA LEUCOPYRUS IN SWISS ALBINO MICE

Abstract

Author(s): S. Amreen Sultana*, A. Laly Steven, B. Mounica, N. Rama Lakshmi, D. Eswar Tony, N. Rama Rao

In the present study Anti convulsant activity of Methanolic and aqueous extracts of leaves of Securinega leucopyrus were evaluated.Materials & Methods: Anti convulsant activity of Methanol ic and Aqueous extracts of leaves of Securinega leucopyrus were evaluated by Strychnine-induced seizure in mice. The Methanolic and Aqueous extracts of leaves of Securinega leucopyrus (200mg/kg) treat the convulsions and produced significant reductions in severity and frequency of seizures. Standard drug Diazepam (2mg/kg, i.p) has shown significant reduction in frequency of seizures whereas methanolic extract of leaves of Securinega leucopyrus (MESL) and aqueous extract of leaves of Securinega leucopyrus (AESL) at a dose of 200 mg/kg, oral significantly (P<0.05) reduced frequency of Strychnine induced convulsion.Conclusion: Both MESL and AESL showed marked reductionin the frequency of seizuresbut the efficiency of MESL is more when compared to AESL. The results suggest that the MESL and AESL have the ability to control the extent and severity of seizures in mice. Keywords: Securinega leucopyrus, Anti convulsant, Strychnine, Mice, Seizure