Journal of Harmonized Research in Pharmacy

EVALUATION OF ANTI-DIARRHOEAL ACTIVITY OF HYDRO-ALCOHOLIC LEAF EXTRACT OF PHLOGACANTHUS THYRSIFLORUS IN ALBINO WISTAR RATS.

Abstract

Author(s): Ashish K.Paharia*, Dr. A.Pandurangan

Objective: In the present study Anti-diarrhoeal activity of Hydroalcoholic extracts of Leaves of Phlogacanthus thyrsiflorus were investigated. Material & Method: Anti-diarrhoeal activity of Hydroalcoholic extracts of Leaves of Phlogacanthus thyrsiflorus were evaluated by castor oilinduced-diarrhoea model & small intestine transit model in experimental rats. The Hydroalcoholic extracts of Leaves of Phlogacanthus thyrsiflorus (100 & 200 mg/kg) treat the Diarrhoea and produced significant reductions in fecal output and frequency of droppings. Standard drug Loperamide (3 mg/kg, p.o) was shown significant reductions in fecal output and frequency of droppings whereas HEPT at the doses of 100 and 200 mg/kg p.o significantly (P<0.05) reduced the castor-oil induced frequency and consistency of diarrhoea. Conclusion : The HEPT showed marked reduction in the number of diarrhoea stools as well as a modest reduction in intestinal transit. The results obtained establish the efficacy and substantiate the folklore claim as an anti- diarrheal agent. Further studies are needed to completely understand the mechanism of anti-diarrhoeal action of Phlogacanthus thyrsiflorus leaf.