Journal of Harmonized Research in Pharmacy

EVALUATION OF HEPATOPROTECTIVE EFFECT OF LENZITUS BETULINA AGAINST PARACETAMOL INDUCED HEPATIC DAMAGE IN RATS

Abstract

Author(s): C. Sundaramoorthi, R. Jayaraman, Johnson, Vipul, Riyas, Kamal Kumar Dhariya

In present work preliminary phytochemical analysis and pharmacological evaluation methanolic extract of lenzitus betuline (MELB) was done. Phytochemical analysis was done for lenzitus betulina. Agai nst toxicity produced by administering a combination of antipyretic drugs in paracetamol (PCM) 200mg/kg each for 21 days in male Wister rats. MELB was administered in two graded doses 0f 200 and 400mg/kg orally. Hepatoprotective effect of MELB WAS evident in the doses of 200 and 400 mg/kg as there was a significant decrease in SGOT, SGPT, ALP, Total and direct bilirubin levels treated groups in comparison to only induced groups without treatment. The reverse condition is seen in total protein level. The glutathione content and the activity of antioxidant enzyme such as superoxide dismutase, catalase, glutathione peroxidise and glutathione reductase were estimated in liver which shows that treatment with mushroom extract brought the enzyme levels close to normality. Histopathology of the liver section of the animals with the MELB further confirms the hepatoprotective activity.