Journal of Harmonized Research in Pharmacy

FORMULATION DEVELOPMENT AND EVALUATION OF LOZENGES CONTAINING POLYHERBAL EXTRACT OF CINNAMOMUM TAMALA AND SPILANTHES ACMELLA

Abstract

Author(s): Pooja C. Deshpande, Dinesh M. Biyani, Avinash O, Maske Dr.Milind Umekar and Bhushan Hatwar

In recent year, the growing demand of herbal has lead to a quantum jump in a volume of plant material traded within and across the country. Cinnamomum Tamala and Spilanthes Acmella is an important medicinal plant, commonly known as Tejpatta (Cinnamomum Tamala ) and Akarkara (Spilanthes Acmella) which rich source of therapeutic constituent. The aim of this research to develop of modern dosage form such as lozenges associated with an extended period of local remedy with beneficial therapeutic effect. The combination of Cinnamomum Tamala leaves and Spilanthes Acmella flowers extract exhibit antimicrobial property against the selected microorganism (staphylococcus aureus, streptococcus mutans and Escherichia coli). The qualitative Phytochemical screening of ethanol, methanol and petroleum ether extracts of both Cinnamomum Tamala leaves and Spilanthes Acmella flowers extract was performed and confirmed the presence of many phytochemicals like alkaloids, flavonoids, glycosides and triterpenes . From the result obtained it can be concluded that the optimized formula F3 was selected for the formulation of tablet lozenges and was prepared by direct compression method which exhibit optimum friability, weight uniformity, hardness and disintegration time.