Journal of Harmonized Research in Pharmacy

FORMULATION & EVALUATION OF TRANSDERMAL PATCH OF TOLBUTAMIDE

Abstract

Author(s): Ganju Eisha* and Ganju Kuldeep

The aim of the present investigation was to prepare tolbutamide transdermal patches by solvent casting technique using the HPMC and PVP polymer in different ratios. The systems were evaluated for var ious in- vitro parameters like (Thickness, Folding endurance, Moisture content, Moisture uptake, etc). In- vitro permeation studies were performed by using Franz diffusion cell. Variations in drug permeation profile were observed among various formulations. From all the formulations, formulation P4 was selected as the best formulation and formulation was stable for period of 90 days stability study. Keywords: Transdermal drug delivery, Matrix patch preparation, Membrane controlled Patch, tolbutamide, HPMC, PVP, In- vitro skin permeation studies.