Journal of Harmonized Research in Pharmacy

INFLUENCE OF SODIUM SACCHARIN IN BLOOD MEDIUM USING CYCLIC VOLTAMMETRIC METHOD AT NANO-SENSOR

Abstract

Author(s): Prof. Dr. Muhammed Mizher Radhi, Assistant Prof. Dr. Yousif Kadim Abdul Amir, Anfal Ismael Ibrahim

Several chemical compounds were used as an alternative of natural sugar for diabetic patients such as sodium saccharin (NaSc). This compound has unknown side effects so far on human health especially on the blood components as oxidative or anti-oxidative reagents, so the study is very important in this field. In this study, it was used a high-precision sensor (glassy carbon electrode GCE modified with carbon nanotubes CNT) in detection of electrochemical properties for sodium saccharin compound in the blood medium by cyclic voltammetric technique. It was found that NaSc has oxidation-reduction current peaks in blood medium at 450 and -900 mV respectively; different concentration, scan rates and pH. Also, the study was included the determination each of current ratio (Ipa/Ipc), potential peak separation (?E) and diffusion coefficient (Df) value on the preparation nano-sensor. In application study of NaSc in blood medium, it was found the effect of each of vitamin E, ascorbic acid (AA) and folic acid (FA) on the redox current peaks of NaSc in the blood medium at different concentrations. Keywords: Sodium saccharin, cyclic voltammetry, blood medium, CNT/GCE