Journal of Harmonized Research in Pharmacy

PHARMACOLOGICAL EVALUATION OF EXTRACT OF TANACETAM PARTHENIUM .L FLOWER DISK FLORETS FOR ANTINOCICEPTIVE ACTIVITY IN RODENTS

Abstract

Author(s): V. Sri Padmavathi, Y. Nagalakshmi, P. Srilakshmi, P. Sandeep, D. Eswar Tony

Pain is a symptom of many diseases requiring treatment with analgesics. Severe pain due to cancer metastases needs the use of strong analgesics that means opioid drugs. The addiction liability of opi oids led to intensive research for compounds without this side effect. Many approaches have been used to differentiate the various actions of strong analgesics by developing animal models not only for analgesic activity but also for addiction liability. The study was undertaken to evaluate the analgesic activity of Tanacetam parthenium flower extracts using Tail flick method. The study comprised of three treatment groups (control, standard and test – Tanacetaam parthenium aqueous extract) all with five animals in each group. At the end of the study aqueous extract showed significant analgesic activity when compared with standard and control treatment groups.