Journal of Harmonized Research in Pharmacy

REVIEW ON NON-DESTRUCTIVE QUANTIFICATION FOR SOLID DOSAGE FORMS: A NEXTGEN IN PHARMACO-ECONOMICS.

Abstract

Author(s): Manoj Kumar Katual, Pooja Bhardwaj, SL Harikumar

The non-destructive techniques are now-a-days gaining popularity for the evaluation of solid dosage forms in pharmaceutical industries an alternative for the destructive techniques methods of evaluat ion. Non-Destructive techniques are advantageous over the destructive techniques. In non-destructive techniques, FTIR and IR Spectroscopy techniques are used. The research is continuing to find out a suitable alternative tool to provide the safety and efficacy of pharmaceuticals without destroying the same. It is expected to overcome the constraints related cost efficiency of pharmaceuticals sacrificed for quality control parameters. Approx. 10% of total finished products engaged in analytical process which ultimately accelerate price of final product A non-destructive evaluation of tablets is possible with the application of Fourier transform infrared spectroscopy, near-infrared spectroscopy, Optical coherence tomography (OCT) and terahertz pulsed imaging (TPI), Raman spectroscopy, and appropriate statistical techniques. The advantages of non-destructive techniques are, rapid & reproducible techniques, more precise evaluation of products (e.g. tablets, capsules etc.), less wastage of pharmaceuticals, low production cost, maintenance of dose accuracy. The new ideas about non-destructive evaluation techniques are considered to be advantageous to destructive analytical techniques and will create a new generation of safe and economic pharmaceuticals.