SINGLE DOSE OF INTRA-MUSCULAR PLATELET RICH PLASMA SUPPRESS THE INCREASE IN PLASMA HEPCIDIN LEVEL: PROTECT ROLE IN EXERCISE INDUCED IRON LOSS?
Abstract
Author(s): Zekine Punduk
Background: In general, platelet rich plasma (PRP) injection treatment is used for skeletal muscle injury. PRP is regulated tissue regeneration by controlling autocrine and paracrine biomolecules inc luding growth factors. We recently have reported that PRP administration reverses in plasma iron levels response to post-exercise recovery days. As a continuation of this study that PRP can be affected on iron regulated hormone plasma hepcidin levels during the post-exercise inflammation process. The exercise-induced muscle damage exercise (EIMDE) used as an acute model for muscle inflammation. The purpose of this investigation the effects of intramuscular delivery of PRP on hematologic and hepcidin responses and recovery strategy muscle inflammation induced by exhaustive muscle damage exercise. Methods: Volunteers were assigned to a control (n =6) and PRP application (PRP, n=6) and they performed exhaustive exercise with maximal voluntary contraction of the elbow. Then, saline or PRP injections was applied on painfully arm of the subjects. Blood samples were obtained in the morning to establish a baseline value and also following the injections 1., 2.,3. and 4 days post-exercise. Results: The baseline levels in white blood cells (WBC), neutrophils (Neut), lymphocytes (Lymph), red blood cells (RBC), hemoglobin (Hb), and hepcidin levels were similar in both saline and PRP injections group. However, 24-hour following exercise a significant increase in Hb, WBC, Neut, hepcidin were observed in control during the recovery days. Interestingly, PRP administration inhibited effects on these parameters. Conclusion: PRP administration improved inflammation by suppressing the increase hepcidin level in the post-exercise and it may favourable effect in the exercise induced iron losses. Key Words: Hepcidin; exercise-induced muscle damage; platelet rich plasma
