Journal of Harmonized Research in Pharmacy

STUDIES ON MIXED SOLVENCY CONCEPT IN FORMULATION DEVELOPMENT OF ORAL SOLUTION (SYRUP) OF POORLY WATER SOLUBLE DRUGS

Abstract

Author(s): Love Kumar Soni, Shailendra Singh Solanki, Rajesh Kumar Maheshwari

Application of the mixed solvency has been employed in the present research work to develop the oral solution (syrup) formulations of poorly water soluble drugs aceclofenac (as model drug). Due to t he low water solubility of aceclofenac in water, an attempt was made to enhance the solubility of drug by adding cost effective additives (combination of solubilizers as mixed solvent system) which could increase the solubility as well as stabilized the developed oral solution (syrup) formulation. On the basis of solubility studies mixed solvent oral solution formulations of aceclofenac were developed. Formulations were characterized by FTIR and Raman spectroscopy. Various properties of solution such as pH, viscosity, specific gravity and refractive index were also studied. The physical and chemical stability studies were carried out to examine the physical and chemical stability of an optimal oral solution (syrup) formulation of aceclofenac. All the formulations were physically, chemically and microbiologically stable for more than three months.