THE PROOXIDANT-ANTIOXIDANT SYSTEM IS THE PRIMARY STAGE OF THE ANSWER OF ORGANISM ON UNBALANCED DIET
Abstract
Author(s): Bozhkov A. I., Nikitchenko Yu.V., Sheremet A. A., Bozhkov A.A.
Abstract The influence of the by animal proteins and vitamins unbalanced diet (PVU diet) on some characteristics of prooxidant and antioxidant systems activity in rats obtaining on such diet during 2 months was investigated. This diet was not influence the somatometric characteristics of animals but the products of free radical reactions increased in liver microsomes and mitochondria and also in the blood serum. Such changes of prooxidant activity were shown simultaniusely with decreased activity of glutathione peroxidase and other antioxidant enzymes. The changes in the balance of pro – and antioxidants not depended on age of experimental animals. Addition of Aronia melanocarpa fruits to the diet of animals did not affect the activity of antioxidant enzymes, but decreased the content of peroxidation products to the control level. This effect is due to the presence of antioxidant non enzymatic components in fruits of Aronia melanocarpa. The peroxidation in animals on the PVU can be achieved by the inclusion of sodium selenite in such diet. PVU-induced changes in the prooxidant system of the animals can be removed by different strategies. Keywords: Unbalanced diet, Aronia melanocarpa, antioxidant enzymes.
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